Purpose: Pancreatic cancer is a severe indication with short expected survival despite
surgery and/or combination chemotherapeutics. Checkpoint blockade antibodies are …

Background Transplantation of beta cells by pancreas or islet transplantation is the
treatment of choice for a selected group of patients suffering from type 1 diabetes mellitus …

MODY1 is a maturity-onset monogenic diabetes, caused by heterozygous mutations of the
HNF4A gene. To date the cellular and molecular mechanisms leading to disease onset …

Prior to transplantation into individuals with type 1 diabetes, in vitro assays are used to
evaluate the quality, function and survival of isolated human islets. In addition to the …

Cell replacement therapies hold great therapeutic potential. Nevertheless, our knowledge of
the mechanisms governing the developmental processes is limited, impeding the quality of …

Background. When transplanted human pancreatic islets are exposed to blood during
intraportal infusion, an innate immune response is triggered. This instant blood-mediated …

Beta cell-specific surface targets are required for non-invasive monitoring of beta cell mass,
which could be used for evaluation of new diabetes treatments as well as to help unravel …

Adipose-derived mesenchymal stem cells (ASCs) release factors beneficial for islets in vitro
and protect against hyperglycemia in rodent models of diabetes. Oxygen tension has been …

Current published protocols for targeted differentiation of human stem cells toward
pancreatic β-cells fail to deliver sufficiently mature cells with functional properties …

Aim The variation in quality between the human islet samples represents a major problem
for research, especially when used as control material. The assays assessing the quality of …