Streptococcus pneumoniae is an infectious pathogen responsible for millions of deaths
worldwide. Diseases caused by this bacterium are classified as pneumococcal diseases …

Streptococcus pneumoniae is a major pathogen of humans, causing diseases such as
pneumonia and meningitis. The organism produces several virulence factors that are …

Streptococcus pneumoniae is a leading cause of pneumonia, meningitis, and sepsis.
Pneumococci can be divided into> 90 serotypes that show differences in the pathogenicity …

Host-to-host transmission is a critical step for infection. Here we studied transmission of the
opportunistic pathogen Streptococcus pneumoniae in an infant mouse model. Transmission …

The cholesterol-dependent cytolysins (CDCs) are a large family of pore-forming toxins that
are produced, secreted and contribute to the pathogenesis of many species of Gram-positive …

The cholesterol-dependent cytolysins are pore-forming toxins. Pneumolysin is the cytolysin
produced by Streptococcus pneumoniae and is a key virulence factor. The protein contains …

The cholesterol-dependent cytolysin (CDC) pneumolysin (Ply) is a key virulence factor of
Streptococcus pneumoniae. Membrane cholesterol is required for the cytolytic activity of this …

Streptococcus pneumoniae is a major cause of otitis media, pneumonia, meningitis, and
septicemia in humans. The host defense against this pathogen largely depends on bacterial …

Cholesterol dependent cytolysins are important in the ability of some bacteria to cause
disease in man and animals. Pneumolysin (PLY) plays a key role in the diseases caused by …

BACKGROUND: Pneumococcal vaccines based on conserved protein antigens have the
potential to offer expanded protection against Streptococcus pneumoniae. OBJECTIVE: This …