Small‐molecule prodrug nanoassemblies: an emerging nanoplatform for anticancer drug delivery

G Li, B Sun, Y Li, C Luo, Z He, J Sun - Small, 2021 - Wiley Online Library
The antitumor efficiency and clinical translation of traditional nanomedicines is mainly
restricted by low drug loading, complex preparation technology, and potential toxicity …

Theranostic fluorescent probes

A Sharma, P Verwilst, M Li, D Ma, N Singh… - Chemical …, 2024 - ACS Publications
The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal
control, in the context of drug delivery makes theranostic fluorescent probes an attractive …

Diverse applications of nanomedicine

B Pelaz, C Alexiou, RA Alvarez-Puebla, F Alves… - ACS …, 2017 - ACS Publications
The design and use of materials in the nanoscale size range for addressing medical and
health-related issues continues to receive increasing interest. Research in nanomedicine …

Self-assembled redox dual-responsive prodrug-nanosystem formed by single thioether-bridged paclitaxel-fatty acid conjugate for cancer chemotherapy

C Luo, J Sun, D Liu, B Sun, L Miao, S Musetti, J Li… - Nano …, 2016 - ACS Publications
Chemotherapeutic efficacy can be greatly improved by developing nanoparticulate drug
delivery systems (nano-DDS) with high drug loading capacity and smart stimulus-triggered …

Molecular mechanisms and genetics of oxidative stress in Alzheimer's disease

F Cioffi, RHI Adam, K Broersen - Journal of Alzheimer's …, 2019 - content.iospress.com
Alzheimer's disease is the most common neurodegenerative disorder that can cause
dementia in elderly over 60 years of age. One of the disease hallmarks is oxidative stress …

ROS stress in cancer cells and therapeutic implications

H Pelicano, D Carney, P Huang - Drug resistance updates, 2004 - Elsevier
Reactive oxygen species (ROS) are constantly generated and eliminated in the biological
system, and play important roles in a variety of normal biochemical functions and abnormal …

Mitochondrial metabolism of reactive oxygen species

AY Andreyev, YE Kushnareva, AA Starkov - Biochemistry (Moscow), 2005 - Springer
Oxidative stress is considered a major contributor to etiology of both “normal” senescence
and severe pathologies with serious public health implications. Mitochondria generate …

[PDF][PDF] Oxidative stress: animal adaptations in nature

KB Storey - Brazilian journal of medical and biological research, 1996 - researchgate.net
As a consequence of aerobic life, an organism must deal with the continuous generation of
reactive oxygen species (O2-, H2O2,• OH) as byproducts of metabolism and defend itself …

Tumor redox heterogeneity‐responsive prodrug nanocapsules for cancer chemotherapy

J Wang, X Sun, W Mao, W Sun, J Tang… - Advanced …, 2013 - Wiley Online Library
Nanocarriers have been extensively explored for cancer drug delivery to increase the
solubility of the drug in water [1] and tumor accumulation [2] by means of its enhanced …

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

N Zamzami, P Marchetti, M Castedo… - The Journal of …, 1995 - rupress.org
Programmed cell death (PCD) is a physiological process commonly defined by alterations in
nuclear morphology (apoptosis) and/or characteristic stepwise degradation of chromosomal …