Microbiome-based therapeutics
MT Sorbara, EG Pamer - Nature Reviews Microbiology, 2022 - nature.com
Symbiotic microorganisms inhabiting the gastrointestinal tract promote health by decreasing
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …
Microbiota-mediated colonization resistance: mechanisms and regulation
G Caballero-Flores, JM Pickard, G Núñez - Nature Reviews …, 2023 - nature.com
A dense and diverse microbial community inhabits the gut and many epithelial surfaces.
Referred to as the microbiota, it co-evolved with the host and is beneficial for many host …
Referred to as the microbiota, it co-evolved with the host and is beneficial for many host …
[HTML][HTML] The microbiota-gut-brain axis
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …
[HTML][HTML] Microbiota, gut health and chicken productivity: what is the connection?
JM Diaz Carrasco, NA Casanova… - Microorganisms, 2019 - mdpi.com
Gut microbiota and its relationship to animal health and productivity in commercial broiler
chickens has been difficult to establish due to high variability between flocks, which derives …
chickens has been difficult to establish due to high variability between flocks, which derives …
[HTML][HTML] A gut commensal-produced metabolite mediates colonization resistance to Salmonella infection
A Jacobson, L Lam, M Rajendram, F Tamburini… - Cell host & …, 2018 - cell.com
The intestinal microbiota provides colonization resistance against pathogens, limiting
pathogen expansion and transmission. These microbiota-mediated mechanisms were …
pathogen expansion and transmission. These microbiota-mediated mechanisms were …
Host microbiota constantly control maturation and function of microglia in the CNS
D Erny, AL Hrabě de Angelis, D Jaitin… - Nature …, 2015 - nature.com
As the tissue macrophages of the CNS, microglia are critically involved in diseases of the
CNS. However, it remains unknown what controls their maturation and activation under …
CNS. However, it remains unknown what controls their maturation and activation under …
[HTML][HTML] Bacteroides Fragilis in the gut microbiomes of Alzheimer's disease activates microglia and triggers pathogenesis in neuronal C/EBPβ transgenic mice
Gut dysbiosis contributes to Alzheimer's disease (AD) pathogenesis, and Bacteroides strains
are selectively elevated in AD gut microbiota. However, it remains unknown which …
are selectively elevated in AD gut microbiota. However, it remains unknown which …
[HTML][HTML] Stable engraftment of Bifidobacterium longum AH1206 in the human gut depends on individualized features of the resident microbiome
MX Maldonado-Gómez, I Martínez, F Bottacini… - Cell host & …, 2016 - cell.com
Live bacteria (such as probiotics) have long been used to modulate gut microbiota and
human physiology, but their colonization is mostly transient. Conceptual understanding of …
human physiology, but their colonization is mostly transient. Conceptual understanding of …
Genome-guided design of a defined mouse microbiota that confers colonization resistance against Salmonella enterica serovar Typhimurium
S Brugiroux, M Beutler, C Pfann, D Garzetti… - Nature …, 2016 - nature.com
Protection against enteric infections, also termed colonization resistance, results from
mutualistic interactions of the host and its indigenous microbes. The gut microbiota of …
mutualistic interactions of the host and its indigenous microbes. The gut microbiota of …
High-avidity IgA protects the intestine by enchaining growing bacteria
Vaccine-induced high-avidity IgA can protect against bacterial enteropathogens by directly
neutralizing virulence factors or by poorly defined mechanisms that physically impede …
neutralizing virulence factors or by poorly defined mechanisms that physically impede …