The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease
The chemokine receptor CXCR4 and its ligand CXCL12 play an important homeostatic
function by mediating the homing of progenitor cells in the bone marrow and regulating their …
function by mediating the homing of progenitor cells in the bone marrow and regulating their …
SDF-1α as a therapeutic stem cell homing factor in myocardial infarction
SK Ghadge, S Mühlstedt, C Özcelik, M Bader - Pharmacology & …, 2011 - Elsevier
Myocardial infarction is associated with persistent muscle damage, scar formation and
depressed cardiac performance. Recent studies have demonstrated the clinical significance …
depressed cardiac performance. Recent studies have demonstrated the clinical significance …
Stromal Cell–Derived Factor-1α Confers Protection Against Myocardial Ischemia/Reperfusion Injury: Role of the Cardiac Stromal Cell–Derived Factor-1α–CXCR4 Axis
X Hu, S Dai, WJ Wu, W Tan, X Zhu, J Mu, Y Guo… - Circulation, 2007 - Am Heart Assoc
Background—Stromal cell–derived factor-1α (SDF-1α) binding to its cognate receptor,
CXCR4, regulates a variety of cellular functions such as stem cell homing, trafficking, and …
CXCR4, regulates a variety of cellular functions such as stem cell homing, trafficking, and …
Chemokines in vascular dysfunction and remodeling
A Schober - Arteriosclerosis, thrombosis, and vascular biology, 2008 - Am Heart Assoc
Vascular remodeling stands for structural changes of the vessel wall in response to various
noxious stimuli, which results in reorganization of the vessel wall architecture. Luminal …
noxious stimuli, which results in reorganization of the vessel wall architecture. Luminal …
A systematic assessment of cardiovascular outcomes in the saxagliptin drug development program for type 2 diabetes
R Frederich, JH Alexander, FT Fiedorek… - Postgraduate …, 2010 - Taylor & Francis
Objective: The objective was to assess the relative risk (RR) for cardiovascular (CV) events
across all 8 randomized phase 2/3 trials evaluating saxagliptin in patients with type 2 …
across all 8 randomized phase 2/3 trials evaluating saxagliptin in patients with type 2 …
Chemokines in vascular remodeling
A Schober, A Zernecke - Thrombosis and haemostasis, 2007 - thieme-connect.com
The arterial vessel wall response to a variety of injuries consists in structural changes, which
can result in luminal narrowing and aggravation of the underlying disease. This arterial …
can result in luminal narrowing and aggravation of the underlying disease. This arterial …
[HTML][HTML] Stromal derived factor 1α: a chemokine that delivers a two-pronged defence of the myocardium
Alleviating myocardial injury associated with ST elevation myocardial infarction is central to
improving the global burden of coronary heart disease. The chemokine stromal cell-derived …
improving the global burden of coronary heart disease. The chemokine stromal cell-derived …
Crosstalk between SDF-1/CXCR4 and SDF-1/CXCR7 in cardiac stem cell migration
D Chen, Y Xia, K Zuo, Y Wang, S Zhang, D Kuang… - Scientific reports, 2015 - nature.com
Stromal cell-derived factor 1 (SDF-1) is a chemokine that can be expressed in injured
cardiomyocytes after myocardial infarction (MI). By combining with its receptor CXCR4, SDF …
cardiomyocytes after myocardial infarction (MI). By combining with its receptor CXCR4, SDF …
Lentiviral gene transfer of SDF-1α to wounds improves diabetic wound healing
AT Badillo, S Chung, L Zhang, P Zoltick… - Journal of Surgical …, 2007 - Elsevier
BACKGROUND: Chronic wounds continue to be a major clinical problem and novel
therapeutic approaches are needed. We have previously demonstrated that treatment of …
therapeutic approaches are needed. We have previously demonstrated that treatment of …
Hypoxia inducible factor-1α, endothelial progenitor cells, monocytes, cardiovascular risk, wound healing, cobalt and hydralazine: a unifying hypothesis
Bone marrow-derived mononuclear cells differentiate into endothelial cells in adult animals,
including humans. These cells, endothelial progenitor cells (EPCs), play central roles in …
including humans. These cells, endothelial progenitor cells (EPCs), play central roles in …