The chemokine receptor CXCR4 and its ligand CXCL12 play an important homeostatic
function by mediating the homing of progenitor cells in the bone marrow and regulating their …

Myocardial infarction is associated with persistent muscle damage, scar formation and
depressed cardiac performance. Recent studies have demonstrated the clinical significance …

Background—Stromal cell–derived factor-1α (SDF-1α) binding to its cognate receptor,
CXCR4, regulates a variety of cellular functions such as stem cell homing, trafficking, and …

Vascular remodeling stands for structural changes of the vessel wall in response to various
noxious stimuli, which results in reorganization of the vessel wall architecture. Luminal …

Objective: The objective was to assess the relative risk (RR) for cardiovascular (CV) events
across all 8 randomized phase 2/3 trials evaluating saxagliptin in patients with type 2 …

The arterial vessel wall response to a variety of injuries consists in structural changes, which
can result in luminal narrowing and aggravation of the underlying disease. This arterial …

Alleviating myocardial injury associated with ST elevation myocardial infarction is central to
improving the global burden of coronary heart disease. The chemokine stromal cell-derived …

Stromal cell-derived factor 1 (SDF-1) is a chemokine that can be expressed in injured
cardiomyocytes after myocardial infarction (MI). By combining with its receptor CXCR4, SDF …

BACKGROUND: Chronic wounds continue to be a major clinical problem and novel
therapeutic approaches are needed. We have previously demonstrated that treatment of …

Bone marrow-derived mononuclear cells differentiate into endothelial cells in adult animals,
including humans. These cells, endothelial progenitor cells (EPCs), play central roles in …