The immunogenicity of polysaccharides as human vaccines was enhanced by coupling to
protein carriers. Conjugation transformed the T cell-independent polysaccharide vaccines of …

Nearly all licensed vaccines have been developed to confer protection against infectious
diseases by stimulating the production of antibodies by B cells, but the nature of a successful …

Context In the absence of an effective vaccine, serogroup B Neisseria meningitidis (MenB)
remains a major cause of invasive disease in early childhood in developed countries …

A number of countries now include meningococcal vaccines in their routine immunization
programs. This review focuses on different approaches to including meningococcal vaccines …

Since the introduction of monovalent meningococcal serogroup C (MenC) glycoconjugate
(MCC) vaccines and the implementation of national vaccination programmes, the incidence …

Introduction: Globally, the three main pathogens causing serious infections are
Haemophilus influenzae type b, Streptococcus pneumoniae and Neisseria meningitidis …

Vaccines are cost-effective tools for reducing morbidity and mortality caused by infectious
diseases. The rapid evolution of pneumococcal conjugate vaccines, the introduction of …

Randomized, controlled trials are not always possible to evaluate interventions targeting
infectious disease. This is frequently the case when evaluating the population-level impact …

The encapsulated bacteria Streptococcus pneumoniae, Neisseria meningitis, Haemophilus
influenzae, and Streptococcus agalactiae (Group B Streptococcus) have been responsible …

BACKGROUND: Routine administration of quadrivalent meningococcal conjugate vaccine
to adolescents and certain high risk groups is recommended in the United States and …