An update on connexin gap junction and hemichannels in diabetic retinopathy

J González-Casanova, O Schmachtenberg… - International Journal of …, 2021 - mdpi.com
Diabetic retinopathy (DR) is one of the main causes of vision loss in the working age
population. It is characterized by a progressive deterioration of the retinal microvasculature …

[HTML][HTML] Myriad roles for gap junctions in retinal circuits

S Trenholm, GB Awatramani - … : The Organization of the Retina and …, 2019 - ncbi.nlm.nih.gov
Gap junctions are recognized in the electron microscope as dense starchy areas of opposed
membrane between two cells. Small tracer molecules such as Neurobiotin pass through the …

Modeling extracellular stimulation of retinal ganglion cells: theoretical and practical aspects

KE Kish, SF Lempka, JD Weiland - Journal of neural engineering, 2023 - iopscience.iop.org
Objective. Retinal prostheses use electric current to activate inner retinal neurons, providing
artificial vision for blind people. Epiretinal stimulation primarily targets retinal ganglion cells …

An in-silico analysis of electrically evoked responses of midget and parasol retinal ganglion cells in different retinal regions

X Song, S Qiu, MN Shivdasani, F Zhou… - Journal of Neural …, 2022 - iopscience.iop.org
Objective. Visual outcomes provided by present retinal prostheses that primarily target
retinal ganglion cells (RGCs) through epiretinal stimulation remain rudimentary, partly due to …

Spatially selective retinal ganglion cell activation using Low invasive extraocular temporal interference stimulation

X Song, T Guo, S Ma, F Zhou, J Tian… - … journal of neural …, 2025 - pubmed.ncbi.nlm.nih.gov
Conventional retinal implants involve complex surgical procedures and require invasive
implantation. Temporal Interference Stimulation (TIS) has achieved noninvasive and …

The role of gap junctions in cell death and neuromodulation in the retina

G Szarka, M Balogh, ÁJ Tengölics… - Neural Regeneration …, 2021 - journals.lww.com
Vision altering diseases, such as glaucoma, diabetic retinopathy, age-related macular
degeneration, myopia, retinal vascular disease, traumatic brain injuries and others cripple …

Gap Junctions Fine-tune Ganglion Cell Signals to Equalize Response Kinetics within a Given Electrically Coupled Array

G Szarka, A Ganczer, M Balogh, ÁJ Tengölics… - iScience, 2024 - cell.com
Retinal ganglion cells (RGCs) summate inputs and forward a spike train code to the brain in
the form of either maintained spiking (sustained) or a quickly decaying brief spike burst …

Inference of electrical stimulation sensitivity from recorded activity of primate retinal ganglion cells

SS Madugula, R Vilkhu, NP Shah… - Journal of …, 2023 - Soc Neuroscience
High-fidelity electronic implants can in principle restore the function of neural circuits by
precisely activating neurons via extracellular stimulation. However, direct characterization of …

Understanding responses to multi-electrode epiretinal stimulation using a biophysical model

R Vilkhu, P Vasireddy, KE Kish… - Journal of Neural …, 2024 - iopscience.iop.org
Objective. Neural interfaces are designed to evoke specific patterns of electrical activity in
populations of neurons by stimulating with many electrodes. However, currents passed …

A Patient-Specific Computational Framework to Optimize Retinal Stimulation

K Kish - 2023 - deepblue.lib.umich.edu
Electronic visual prostheses stimulate neurons in the visual pathway to create light
perception for blind patients. Electrically induced spots of light are called phosphenes, and …