New insights into the activities and toxicities of the old anticancer drug doxorubicin

SY van der Zanden, X Qiao, J Neefjes - The FEBS journal, 2021 - Wiley Online Library
The anthracycline drug doxorubicin is among the most used—and useful—
chemotherapeutics. While doxorubicin is highly effective in the treatment of various …

Cardiotoxicity of anthracyclines

D Cardinale, F Iacopo, CM Cipolla - Frontiers in cardiovascular …, 2020 - frontiersin.org
Cardiotoxicity is a feared side effect that may limit the clinical use of anthracyclines. It may
indeed affect the quality of life and survival of patients with cancer, regardless of oncological …

Anthracycline chemotherapy and cardiotoxicity

JV McGowan, R Chung, A Maulik, I Piotrowska… - … drugs and therapy, 2017 - Springer
Anthracycline chemotherapy maintains a prominent role in treating many forms of cancer.
Cardiotoxic side effects limit their dosing and improved cancer outcomes expose the cancer …

Cardiovascular complications of cancer therapy: best practices in diagnosis, prevention, and management: part 1

HM Chang, R Moudgil, T Scarabelli… - Journal of the American …, 2017 - jacc.org
Modern cancer therapy has successfully cured many cancers and converted a terminal
illness into a chronic disease. Because cancer patients often have coexisting heart …

Current diagnostic and treatment strategies for specific dilated cardiomyopathies: a scientific statement from the American Heart Association

B Bozkurt, M Colvin, J Cook, LT Cooper, A Deswal… - Circulation, 2016 - Am Heart Assoc
The first classification on this topic categorized cardiomyopathies as heart muscle diseases
with dilated (DCM), hypertrophic, restrictive, arrhythmogenic right ventricular (ARVC), or …

[HTML][HTML] Meteorin-like protein attenuates doxorubicin-induced cardiotoxicity via activating cAMP/PKA/SIRT1 pathway

C Hu, X Zhang, P Song, YP Yuan, CY Kong, HM Wu… - Redox Biology, 2020 - Elsevier
Meteorin-like (METRNL) protein is a newly identified myokine that functions to modulate
energy expenditure and inflammation in adipose tissue. Herein, we aim to investigate the …

Cardiotoxicity of anticancer treatments: epidemiology, detection, and management

G Curigliano, D Cardinale, S Dent… - CA: a cancer journal …, 2016 - Wiley Online Library
Answer questions and earn CME/CNE Cancer and heart disease are the leading causes of
morbidity and mortality in the industrialized world. Modern treatment strategies have led to …

Targeting molecular mechanisms underlying treatment efficacy and resistance in osteosarcoma: a review of current and future strategies

I Lilienthal, N Herold - International journal of molecular sciences, 2020 - mdpi.com
Osteosarcoma is the most common primary malignant bone tumour in children and
adolescents. Due to micrometastatic spread, radical surgery alone rarely results in cure …

Cardiomyopathy in children: classification and diagnosis: a scientific statement from the American Heart Association

SE Lipshultz, YM Law, A Asante-Korang, ED Austin… - Circulation, 2019 - Am Heart Assoc
In this scientific statement from the American Heart Association, experts in the field of
cardiomyopathy (heart muscle disease) in children address 2 issues: the most current …

Dexrazoxane for preventing or reducing cardiotoxicity in adults and children with cancer receiving anthracyclines

EC de Baat, RL Mulder, S Armenian… - Cochrane Database …, 2022 - cochranelibrary.com
Dexrazoxane for preventing or reducing cardiotoxicity in adults and children with cancer
receiving anthracyclines - de Baat, EC - 2022 | Cochrane Library Skip to Content Cookies Our …