Cytochrome P450s (CYPs) are heme-containing monooxygenases that contribute to an
enormous range of enzymatic function including biosynthetic and detoxification roles. This …

Mechanism-based inactivation (MBI) refers to the metabolic bioactivation of a xenobiotic by
cytochrome P450s to a highly reactive intermediate which subsequently binds to the enzyme …

Cytochrome P450 (P450) enzymes are major catalysts involved in the oxidations of most
drugs, steroids, carcinogens, fat-soluble vitamins, and natural products. The binding of …

In comparison to imidazole (IMZ) and 1, 2, 4-triazole (1, 2, 4-TRZ), the isosteric 1, 2, 3-
triazole (1, 2, 3-TRZ) is unrepresented among cytochrome P450 (CYP) inhibitors. This is …

Identification and quantification of the metabolites of drugs and drug candidates are
routinely performed using liquid chromatography-mass spectrometry (LC-MS). The best …

A novel cytochrome P450 enzyme, TxtE, was recently shown to catalyze the direct aromatic
nitration of l‐tryptophan. This unique chemistry inspired us to ask whether TxtE could serve …

The cytochrome P450 superfamily of heme monooxygenases catalyzes important chemical
reactions across nature. The changes in the optical spectra of these enzymes, induced by …

Cytochrome P450s (P450s) are subject to inhibition/inactivation by various chemically
diverse agents, which may interact directly or indirectly with either the P450 prosthetic heme …

The cytochrome P450 (CYP) superfamily of heme monooxygenases is involved in a range of
important chemical biotransformations across nature. Azole-containing molecules have …

During the course of our research efforts to understand the kinetics of human aldehyde
oxidase as a xenobiotic-clearing enzyme, we investigated the effect of eight different …