Genome-wide association studies
Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …
across many genomes to find those statistically associated with a specific trait or disease …
The Hierarchical Taxonomy of Psychopathology (HiTOP): A quantitative nosology based on consensus of evidence
Traditional diagnostic systems went beyond empirical evidence on the structure of mental
health. Consequently, these diagnoses do not depict psychopathology accurately, and their …
health. Consequently, these diagnoses do not depict psychopathology accurately, and their …
Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases
Y Chen, T Lu, U Pettersson-Kymmer, ID Stewart… - Nature …, 2023 - nature.com
Metabolic processes can influence disease risk and provide therapeutic targets. By
conducting genome-wide association studies of 1,091 blood metabolites and 309 metabolite …
conducting genome-wide association studies of 1,091 blood metabolites and 309 metabolite …
Gene–environment correlations across geographic regions affect genome-wide association studies
Gene–environment correlations affect associations between genetic variants and complex
traits in genome-wide association studies (GWASs). Here we showed in up to 43,516 British …
traits in genome-wide association studies (GWASs). Here we showed in up to 43,516 British …
Polygenic architecture of rare coding variation across 394,783 exomes
Both common and rare genetic variants influence complex traits and common diseases.
Genome-wide association studies have identified thousands of common-variant …
Genome-wide association studies have identified thousands of common-variant …
Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in> 1.2 million individuals highlight new therapeutic directions
Major depressive disorder is the most common neuropsychiatric disorder, affecting 11% of
veterans. Here we report results of a large meta-analysis of depression using data from the …
veterans. Here we report results of a large meta-analysis of depression using data from the …
Participation bias in the UK Biobank distorts genetic associations and downstream analyses
While volunteer-based studies such as the UK Biobank have become the cornerstone of
genetic epidemiology, the participating individuals are rarely representative of their target …
genetic epidemiology, the participating individuals are rarely representative of their target …
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction
Behaviors and disorders related to self-regulation, such as substance use, antisocial
behavior and attention-deficit/hyperactivity disorder, are collectively referred to as …
behavior and attention-deficit/hyperactivity disorder, are collectively referred to as …
Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications
As recreational use of cannabis is being decriminalized in many places and medical use
widely sanctioned, there are growing concerns about increases in cannabis use disorder …
widely sanctioned, there are growing concerns about increases in cannabis use disorder …
Cross-trait assortative mating is widespread and inflates genetic correlation estimates
The observation of genetic correlations between disparate human traits has been
interpreted as evidence of widespread pleiotropy. Here, we introduce cross-trait assortative …
interpreted as evidence of widespread pleiotropy. Here, we introduce cross-trait assortative …