The pathological hallmarks of Alzheimer′ s disease (AD)—widespread synaptic and
neuronal loss and the pathological accumulation of amyloid‐beta peptide (Aβ) in senile …

The G-protein coupled receptors for Δ9-tetrahydrocannabinol, the major psychoactive
principle of marijuana, are known as cannabinoid receptors of type 1 (CB1) and 2 (CB2) and …

Exposure to environmental enrichment can beneficially influence the behavior and enhance
synaptic plasticity. The aim of the present study was to investigate the mediated effects of …

Aged (20–22 months) male Fischer 344 rats were randomly assigned to sedentary (A-SED),
environmentally-enriched (A-ENR), or exercise (A-EX) conditions. After 10–12 weeks of …

There is now a large volume of data indicating that compounds activating cannabinoid CB1
receptors, either directly or indirectly by preventing the breakdown of endogenous …

Identification of molecular mechanisms underlying early stage Alzheimer's disease (AD) is
important for the development of new therapies against and diagnosis of AD. In this study …

Unlike other neuroinflammatory disorders, like Parkinson's disease, Huntington's disease
and multiple sclerosis, little is still known of the role of the endocannabinoid system in …

The discovery of gene mutations responsible for autosomal dominant Alzheimer's disease
has enabled researchers to reproduce in transgenic mice several hallmarks of this disorder …

Background Environmental enrichment (EE) has been shown to enhance cognitive function
in mouse models of Alzheimer's disease (AD). Magnesium‐L‐threonate (MgT) is a …

'Brain and cognitive reserve'(BCR) refers here to the accumulated neuroprotective reserve
and capacity for functional compensation induced by the chronic enhancement of mental …