[HTML][HTML] An introduction to analytical challenges, approaches, and applications in mass spectrometry–based secretomics
Highlights•Overview of challenges, approaches, and opportunities of LC-MS–based
secretomics.•Guidance for unbiased analysis of secreted proteins from cultured …
secretomics.•Guidance for unbiased analysis of secreted proteins from cultured …
[HTML][HTML] A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung
The lung contains numerous specialized cell types with distinct roles in tissue function and
integrity. To clarify the origins and mechanisms generating cell heterogeneity, we created a …
integrity. To clarify the origins and mechanisms generating cell heterogeneity, we created a …
Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA-mutated cancer
Recent studies have pointed to PARP1 trapping as a key determinant of the anticancer
effects of PARP1 inhibitors (PARPi). We identified RNF114, as a PARylation-dependent, E3 …
effects of PARP1 inhibitors (PARPi). We identified RNF114, as a PARylation-dependent, E3 …
Expression patterns and prognostic relevance of subtype‐specific transcription factors in surgically resected small‐cell lung cancer: an international multicenter study
Z Megyesfalvi, N Barany, A Lantos… - The Journal of …, 2022 - Wiley Online Library
The tissue distribution and prognostic relevance of subtype‐specific proteins (ASCL1,
NEUROD1, POU2F3, YAP1) present an evolving area of research in small‐cell lung cancer …
NEUROD1, POU2F3, YAP1) present an evolving area of research in small‐cell lung cancer …
Endocrine and paracrine characteristics of neuroendocrine prostate cancer
T Arman, PS Nelson - Frontiers in Endocrinology, 2022 - frontiersin.org
Prostate cancer is a common malignancy affecting men worldwide. While the vast majority of
newly diagnosed prostate cancers are categorized as adenocarcinomas, a spectrum of …
newly diagnosed prostate cancers are categorized as adenocarcinomas, a spectrum of …
IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells
Cancer-associated fibroblasts (CAFs) in the tumor microenvironment are often linked to drug
resistance. Here, we found that coculture with CAFs or culture in CAF-conditioned medium …
resistance. Here, we found that coculture with CAFs or culture in CAF-conditioned medium …
Neuropilin-2 axis in regulating secretory phenotype of neuroendocrine-like prostate cancer cells and its implication in therapy resistance
Neuroendocrine (NE)-like tumors secrete various signaling molecules to establish paracrine
communication within the tumor milieu and to create a therapy-resistant environment. It is …
communication within the tumor milieu and to create a therapy-resistant environment. It is …
Seven key hub genes identified by gene co-expression network in cutaneous squamous cell carcinoma
H Chen, J Yang, W Wu - BMC cancer, 2021 - Springer
Background Cutaneous squamous cell carcinoma (cSCC) often follows actinic keratosis
(AK) and is the second most common skin cancer worldwide. To reduce metastasis risk, it is …
(AK) and is the second most common skin cancer worldwide. To reduce metastasis risk, it is …
BET inhibitors target the SCLC-N subtype of small-cell lung cancer by blocking NEUROD1 transactivation
Small-cell lung cancer (SCLC) is a recalcitrant malignancy that urgently needs new
therapies. Four master transcription factors (ASCL1, NEUROD1, POU2F3, and YAP1) have …
therapies. Four master transcription factors (ASCL1, NEUROD1, POU2F3, and YAP1) have …
Breast cancer cell secretome analysis to decipher miRNA regulating the tumor microenvironment and discover potential biomarkers
Abstract MicroRNA (miRNA/miR) 526 b-and miR655-overexpressed tumor cell-free
secretions regulate the breast cancer tumor microenvironment (TME) by promoting tumor …
secretions regulate the breast cancer tumor microenvironment (TME) by promoting tumor …