The blood–brain barrier (BBB) greatly restricts the entry of biological and engineered
therapeutic molecules into the brain. Due to challenges in translating results from animal …

Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

Macrophages derived from human induced pluripotent stem cells (iPSCs) have the potential
to enable the development of cell-based therapies for numerous disease conditions. We …

Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating
research to improve diagnostics, and to discover and test novel preventive and curative …

The availability of an autologous transplantable auxiliary liver would dramatically affect the
treatment of liver disease. Assembly and function in vivo of a bioengineered human liver …

To harness the full potential of human pluripotent stem cells (hPSCs) we combined
instrumented stirred tank bioreactor (STBR) technology with the power of in silico process …

Human cerebral organoids derived from induced pluripotent stem cells (iPSCs) provide
novel tools for recapitulating the cytoarchitecture of human brain and for studying biological …

Aiming at clinical translation, robust directed differentiation of human pluripotent stem cells
(hPSCs), preferentially in chemically defined conditions, is a key requirement. Here …

Self-assembly of solid organs from single cells would greatly expand applicability of
regenerative medicine. Stem/progenitor cells can self-organize into micro-sized organ units …

Stem cell research endeavors to generate specific subtypes of classically defined" cell
types." Here, we generate> 90% pure human artery or vein endothelial cells from pluripotent …