Intrinsically determined turnover underlies broad heterogeneity in plasma-cell lifespan
Antibodies produced by antibody-secreting plasma cells (ASCs) underlie multiple forms of
long-lasting immunity. Here we examined the mechanisms regulating ASC turnover and …
long-lasting immunity. Here we examined the mechanisms regulating ASC turnover and …
IL-21R signal reprogramming cooperates with CD40 and BCR signals to select and differentiate germinal center B cells
Both B cell receptor (BCR) and CD40 signaling are rewired in germinal center (GC) B cells
(GCBCs) to synergistically induce c-MYC and phosphorylated S6 ribosomal protein (p-S6) …
(GCBCs) to synergistically induce c-MYC and phosphorylated S6 ribosomal protein (p-S6) …
Molecular mechanisms insulating proliferation from genotoxic stress in B lymphocytes
NE Wright, M Mandal, MR Clark - Trends in Immunology, 2023 - cell.com
In mammals, B cells strictly segregate proliferation from somatic mutation as they develop
within the bone marrow and then mature through germinal centers (GCs) in the periphery …
within the bone marrow and then mature through germinal centers (GCs) in the periphery …
Interleukin-21, acting beyond the immunological synapse, independently controls T follicular helper and germinal center B cells
Germinal centers (GCs), transient structures within B cell follicles and central to affinity
maturation, require the coordinated behavior of T and B cells. IL-21, a pleiotropic T cell …
maturation, require the coordinated behavior of T and B cells. IL-21, a pleiotropic T cell …
Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation
In antibody responses, mutated germinal center B (BGC) cells are positively selected for
reentry or differentiation. As the products from GCs, memory B cells and antibody-secreting …
reentry or differentiation. As the products from GCs, memory B cells and antibody-secreting …
IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation
L Petersone, CJ Wang, NM Edner, A Fabri… - Journal of Experimental …, 2023 - rupress.org
Germinal center (GC) dysregulation has been widely reported in the context of
autoimmunity. Here, we show that interleukin 21 (IL-21), the archetypal follicular helper T …
autoimmunity. Here, we show that interleukin 21 (IL-21), the archetypal follicular helper T …
T-cell help in the germinal center: homing in on the role of IL-21
L Petersone, LSK Walker - International Immunology, 2024 - academic.oup.com
Abstract Interleukin 21 (IL-21) is a pleiotropic cytokine that is overproduced in multiple
autoimmune settings. Provision of IL-21 from follicular helper T cells is an important …
autoimmune settings. Provision of IL-21 from follicular helper T cells is an important …
Maf expression in B cells restricts reactive plasmablast and germinal center B cell expansion
Precise regulation of B cell differentiation is essential for an effective adaptive immune
response. Here, we show that B cell development in mice with B cell-specific Maf deletion is …
response. Here, we show that B cell development in mice with B cell-specific Maf deletion is …
IL‐21 has a critical role in establishing germinal centers by amplifying early B cell proliferation
The proliferation and differentiation of antigen‐specific B cells, including the generation of
germinal centers (GC), are prerequisites for long‐lasting, antibody‐mediated immune …
germinal centers (GC), are prerequisites for long‐lasting, antibody‐mediated immune …
Aberrant zonal recycling of germinal center B cells impairs appropriate selection in lupus
GM Sanchez, ES Hirsch, A VanValkenburg, DP Mayer… - Cell Reports, 2024 - cell.com
Autoimmune diseases such as lupus are characterized by polyclonal B cell activation,
leading to the production of autoantibodies. The mechanism leading to B cell dysregulation …
leading to the production of autoantibodies. The mechanism leading to B cell dysregulation …