HLA-G: too much or too little? Role in cancer and autoimmune disease
JM Martín-Villa, C Vaquero-Yuste… - Frontiers in …, 2022 - frontiersin.org
HLA-G is a non-classical HLA class I molecule with immunomodulatory properties. It was
initially described at the maternal-fetal interface, and it was later found that this molecule …
initially described at the maternal-fetal interface, and it was later found that this molecule …
HLA class I molecules as immune checkpoints for NK cell alloreactivity and anti-viral immunity in kidney transplantation
B Duygu, TI Olieslagers, M Groeneweg… - Frontiers in …, 2021 - frontiersin.org
Natural killer (NK) cells are innate lymphocytes that can kill diseased-or virally-infected cells,
mediate antibody dependent cytotoxicity and produce type I immune-associated cytokines …
mediate antibody dependent cytotoxicity and produce type I immune-associated cytokines …
NKG2A‐checkpoint inhibition and its blockade critically depends on peptides presented by its ligand HLA‐E
C Battin, G Kaufmann, J Leitner, J Tobias… - …, 2022 - Wiley Online Library
NKG2A has emerged as a new immunotherapy target and its blockade with the novel
immune checkpoint inhibitor (ICI) monalizumab can boost both NK cell and CD8+ T cell …
immune checkpoint inhibitor (ICI) monalizumab can boost both NK cell and CD8+ T cell …
The role of HLA-G in tumor escape: manipulating the phenotype and function of immune cells
L Liu, L Wang, L Zhao, C He, G Wang - Frontiers in Oncology, 2020 - frontiersin.org
Human leukocyte antigen-G (HLA-G) is a non-classical major histocompatibility complex
class I (MHC I) molecule, and under physiological conditions, its expression is strictly …
class I (MHC I) molecule, and under physiological conditions, its expression is strictly …
HLA-G genetic diversity and evolutive aspects in worldwide populations
HLA-G is a promiscuous immune checkpoint molecule. The HLA-G gene presents
substantial nucleotide variability in its regulatory regions. However, it encodes a limited …
substantial nucleotide variability in its regulatory regions. However, it encodes a limited …
HLA-E peptide repertoire and dimorphism—centerpieces in the adaptive NK cell puzzle?
Adaptive Natural Killer (NK) cells, a heterogenous subpopulation of human NK cells with a
unique phenotypic and functional signature, became arguably one of the central areas of …
unique phenotypic and functional signature, became arguably one of the central areas of …
Therapeutic applications of adeno-associated virus (AAV) gene transfer of HLA-G in the eye
The purpose of this paper is to review human leukocyte antigen G (HLA-G) in the eye, its
role in immune tolerance, and the potential therapeutic use of AAV gene transfer and …
role in immune tolerance, and the potential therapeutic use of AAV gene transfer and …
The severity of COVID-19 affects the plasma soluble levels of the immune checkpoint HLA-G molecule
JFC Cordeiro, TM Fernandes, DM Toro… - International journal of …, 2022 - mdpi.com
The non-classical histocompatibility antigen G (HLA-G) is an immune checkpoint molecule
that has been implicated in viral disorders. We evaluated the plasma soluble HLA-G (sHLA …
that has been implicated in viral disorders. We evaluated the plasma soluble HLA-G (sHLA …
HLA-G 3'UTR polymorphism diplotypes and soluble HLA-G plasma levels impact cervical cancer susceptibility and prognosis
J Gan, XH Di, ZY Yan, YF Gao, HH Xu - Frontiers in Immunology, 2022 - frontiersin.org
Background Human leukocyte antigen G (HLA-G) is an immune checkpoint molecule with
relevance in several cancers. The aim of this study was to evaluate the potential role of …
relevance in several cancers. The aim of this study was to evaluate the potential role of …
The role of HLA-G in human papillomavirus infections and cervical carcinogenesis
HH Xu, WH Yan, A Lin - Frontiers in immunology, 2020 - frontiersin.org
Human leukocyte antigen (HLA)-G, a non-classical HLA-class I molecule, has a low
polymorphism frequency, restricted tissue distribution and immunoinhibitory property. HLA-G …
polymorphism frequency, restricted tissue distribution and immunoinhibitory property. HLA-G …