The Adhesion family forms a large branch of the pharmacologically important superfamily of
G protein–coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention …

Cyclic AMP is a universal second messenger, produced by a family of adenylyl cyclase (AC)
enzymes. The last three decades have brought a wealth of new information about the …

Several studies have demonstrated the expression of odorant receptors (OR) in various
human tissues and their involvement in different physiological and pathophysiological …

G protein-coupled receptors (GPCRs) represent the largest family of transmembrane
receptors and are prime therapeutic targets. The odorant and taste receptors account for …

A-kinase anchoring proteins (AKAPs) influence the spatial and temporal regulation of cAMP
signaling events. Anchoring of PKA in proximity to certain adenylyl cyclase (AC) isoforms is …

Introduction The G protein-coupled receptors (GPCR) superfamily is among the most widely
exploited targets for therapeutics, with drugs mainly targeting the Rhodopsin, Glutamate and …

Background Marine molluscs, as is the case with most aquatic animals, rely heavily on
olfactory cues for survival. In the mollusc Aplysia californica, mate-attraction is mediated by a …

Odorant-binding proteins (OBPs) represent a highly abundant class of proteins secreted in
the nasal mucus by the olfactory neuroepithelium. These proteins display binding affinity for …

G protein-coupled receptors (GPCRs) are seven-transmembrane-spanning proteins that
mediate cellular and physiological responses. They are critical for cardiovascular function …

Chronic heart failure is one of the most frequent causes of death in humans. Knockout of
type 5 adenylyl cyclase (AC) in mice causes longevity and protection from cardiomyopathy …