The 'ForensOMICS'approach for postmortem interval estimation from human bone by integrating metabolomics, lipidomics, and proteomics

A Bonicelli, HL Mickleburgh, A Chighine, E Locci… - Elife, 2022 - elifesciences.org
The combined use of multiple omics allows to study complex interrelated biological
processes in their entirety. We applied a combination of metabolomics, lipidomics and …

Systematic review on post-mortem protein alterations: Analysis of experimental models and evaluation of potential biomarkers of time of death

MA Sacco, F Cordasco, C Scalise, P Ricci, I Aquila - Diagnostics, 2022 - mdpi.com
Estimating the post-mortem interval (PMI) is a very complex issue due to numerous variables
that may affect the calculation. Several authors have investigated the quantitative and …

An interdisciplinary forensic approach for human remains identification and missing persons investigations

A Dahal, D McNevin, M Chikhani… - Wiley Interdisciplinary …, 2023 - Wiley Online Library
The resolution of unidentified human remains (UHR) and long‐term missing persons (LTMP)
cases is paramount for administrative, legal, and humanitarian reasons. There are various …

Estimating the time of human decomposition based on skeletal muscle biopsy samples utilizing an untargeted LC–MS/MS-based proteomics approach

L Brockbals, S Garrett-Rickman, S Fu, M Ueland… - Analytical and …, 2023 - Springer
Accurate estimation of the postmortem interval (PMI) is crucial in forensic medico-legal
investigations to understand case circumstances (eg narrowing down list of missing persons …

Phylobone: a comprehensive database of bone extracellular matrix proteins in human and model organisms

M Fontcuberta-Rigo, M Nakamura, P Puigbò - Bone Research, 2023 - nature.com
The bone extracellular matrix (ECM) contains minerals deposited on highly crosslinked
collagen fibrils and hundreds of non-collagenous proteins. Some of these proteins are key to …

Insights into the differential preservation of bone proteomes in inhumed and entombed cadavers from Italian forensic caseworks

A Bonicelli, A Di Nunzio, C Di Nunzio… - Journal of Proteome …, 2022 - ACS Publications
Bone is a hard biological tissue and a precious reservoir of information in forensic
investigations as it retains key biomolecules commonly used for identification purposes …

The Texas state donated skeletal collection at the forensic anthropology center at Texas state

TP Gocha, SR Mavroudas, DJ Wescott - Forensic Sciences, 2021 - mdpi.com
The Forensic Anthropology Center at Texas State (FACTS) began accepting whole-body
donations for scientific research and educational purposes under the Texas Anatomical Gift …

A novel method for determining postmortem interval based on the metabolomics of multiple organs combined with ensemble learning techniques

X Lu, J Li, X Wei, N Li, L Dang, G An, Q Du… - International Journal of …, 2023 - Springer
Determining postmortem interval (PMI) is one of the most challenging and essential
endeavors in forensic science. Developments in PMI estimation can take advantage of …

Molecular signatures written in bone proteins of 79 AD victims from Herculaneum and Pompeii

G Ntasi, IR Palomo, G Marino, FD Piaz, E Cappellini… - Scientific reports, 2022 - nature.com
An extensive proteomic analysis was performed on a set of 12 bones of human victims of the
eruption that in AD 79 rapidly buried Pompeii and Herculaneum, allowing the detection of …

Identification of gravity-responsive proteins in the femur of spaceflight mice using a quantitative proteomic approach

K Egashira, Y Ino, Y Nakai, T Ohira, T Akiyama… - Journal of …, 2023 - Elsevier
Although the microgravity (μ-g) environment that astronauts encounter during spaceflight
can cause severe acute bone loss, the molecular mechanism of this bone loss remains …