Abstract Background The Infectious Diseases Society of America is committed to providing
up-to-date guidance on the treatment of antimicrobial-resistant infections. This guidance …

Infections caused by multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-
negative bacteria (GNB), including carbapenem-resistant (CR) Enterobacterales (CRE; …

Abstract Background The Infectious Diseases Society of America (IDSA) is committed to
providing up-to-date guidance on the treatment of antimicrobial-resistant infections. The …

Background Antimicrobial-resistant infections are commonly encountered in US hospitals
and result in significant morbidity and mortality. This guidance document provides …

Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

New Delhi metallo-β-lactamase (NDM) is a metallo-β-lactamase able to hydrolyze almost all
β-lactams. Twenty-four NDM variants have been identified in> 60 species of 11 bacterial …

Carbapenems are considered as last-resort antibiotics for the treatment of infections caused
by multidrug-resistant Gram-negative bacteria. With the increasing use of carbapenems in …

Carbapenemases are β-lactamases belonging to different Ambler classes (A, B, D) and can
be encoded by both chromosomal and plasmid-mediated genes. These enzymes represent …

The management of carbapenem-resistant infections is often based on polymyxins,
tigecycline, aminoglycosides and their combinations. However, in a recent systematic …

The rise in antimicrobial resistance (AMR) continues to be a global crisis [1, 2]. Collectively,
antimicrobial resistant pathogens caused more than 2.8 million infections and over 35,000 …