Gadolinium chloride improves the course of TNBS and DSS-induced colitis through protecting against colonic mucosal inflammation
Inflammatory macrophages in colonic mucosa are the leading drivers of the pathology
associated with inflammatory bowel disease (IBD). Here we examined whether gadolinium …
associated with inflammatory bowel disease (IBD). Here we examined whether gadolinium …
Splenectomy in trauma patients is associated with an increased risk of postoperative type II diabetes: a nationwide population-based study
Background Animal studies indicate that splenocytes may act as precursors of β-islet
secretory cells in the pancreas. This study aimed to assess the risk of postoperative type II …
secretory cells in the pancreas. This study aimed to assess the risk of postoperative type II …
GTS-21 attenuates loss of body mass, muscle mass, and function in rats having systemic inflammation with and without disuse atrophy
SJ Schaller, M Nagashima, M Schönfelder… - … -European Journal of …, 2018 - Springer
Muscle changes of critical illness are attributed to systemic inflammatory responses and
disuse atrophy. GTS-21 (3-(2, 4-dimethoxy-benzylidene) anabaseine), also known as DMBX …
disuse atrophy. GTS-21 (3-(2, 4-dimethoxy-benzylidene) anabaseine), also known as DMBX …
Prolactin anterior pituitary expression and circulating levels are reduced in obese and diabetic rats: role of TGF-β and TNF-α
M Lemini, X Ruiz-Herrera… - American Journal …, 2015 - journals.physiology.org
The levels of the hormone prolactin (PRL) are reduced in the circulation of patients with
Type 2 diabetes and in obese children, and lower systemic PRL levels correlate with an …
Type 2 diabetes and in obese children, and lower systemic PRL levels correlate with an …
Hepatocytic AP-1 and STAT3 contribute to chemotaxis in alphanaphthylisothiocyanate-induced cholestatic liver injury
Y Luo, J Kang, J Luo, Z Yan, S Li, Z Lu, Y Song… - Toxicology Letters, 2023 - Elsevier
The development of cholestatic liver injury (CLI) involves inflammation, but the dominant
pathway mediating the chemotaxis is not yet established. This work explored key signaling …
pathway mediating the chemotaxis is not yet established. This work explored key signaling …
Pancreatic digestive enzyme blockade in the small intestine prevents insulin resistance in hemorrhagic shock
FA DeLano, GW Schmid-Schönbein - Shock, 2014 - journals.lww.com
Hemorrhagic shock is associated with metabolic defects, including hyperglycemia and
insulin resistance, but the mechanisms are unknown. We recently demonstrated that …
insulin resistance, but the mechanisms are unknown. We recently demonstrated that …
Macrophage-specific transgenic expression of cholesteryl ester hydrolase attenuates hepatic lipid accumulation and also improves glucose tolerance in ob/ob mice
J Bie, B Zhao, KE Marqueen, J Wang… - American Journal …, 2012 - journals.physiology.org
Cellular cholesterol homeostasis is increasingly being recognized as an important
determinant of the inflammatory status of macrophages, and a decrease in cellular …
determinant of the inflammatory status of macrophages, and a decrease in cellular …
Deactivation of 12 (S)-HETE through (ω-1)-hydroxylation and β-oxidation in alternatively activated macrophages
T Kriska, MJ Thomas, JR Falck, WB Campbell - Journal of lipid research, 2018 - ASBMB
Polarization of macrophages to proinflammatory M1 and to antiinflammatory alternatively
activated M2 states has physiological implications in the development of experimental …
activated M2 states has physiological implications in the development of experimental …
[HTML][HTML] Polytrauma-induced hepatic stress response and the development of liver insulin resistance
RM Akscyn, JL Franklin, TA Gavrikova… - Biochimica et Biophysica …, 2017 - Elsevier
Insulin resistance and metabolic dysfunction are common following injury. Polytrauma is
defined as combined injuries to more than one body part or organ system, and is common in …
defined as combined injuries to more than one body part or organ system, and is common in …
Regulation of hepatic insulin receptor activity following injury
S Jiang, TA Gavrikova… - American Journal of …, 2014 - journals.physiology.org
Impaired insulin receptor (IR) activity has been found in various models of insulin resistance,
including models of injury or critical illness and Type 2 diabetes. However, mechanisms that …
including models of injury or critical illness and Type 2 diabetes. However, mechanisms that …