Abstract Calcium (Ca 2+) plays a central role in cardiomyocyte excitation-contraction
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …

Impaired myocardial Ca2+ cycling is a critical contributor to the development of heart failure
(HF), causing changes in the contractile function and structure remodeling of the heart …

Mechanosensitive ion channels are widely expressed in the cardiovascular system. They
translate mechanical forces including shear stress and stretch into biological signals. The …

Duchenne muscular dystrophy (DMD) is a muscle degenerating disease caused by
dystrophin deficiency, for which therapeutic options are limited. To facilitate drug …

Cardiomyocyte calcium-handling is the key mediator of cardiac excitation-contraction
coupling. In the healthy heart, calcium controls both electrical impulse propagation and …

In a physiological setting, mitochondria increase oxidative phosphorylation during periods of
stress to meet increased metabolic demand. This in part is mediated via enhanced …

We have developed fluorescence resonance energy transfer (FRET) biosensors with red-
shifted fluorescent proteins (FP), yielding improved characteristics for time-resolved (lifetime) …

A rapid growth in the incidence of diabetes and obesity has transpired to a major heath
issue and economic burden in the postindustrial world, with more than 29 million patients …

Heart failure (HF) therapeutic toolkit would strongly benefit from the availability of ino-
lusitropic agents with a favorable pharmacodynamics and safety profile. Istaroxime is a …

Membrane proteins constitute a substantial fraction of the human proteome, thus
representing a vast source of therapeutic drug targets. Indeed, newly devised technologies …