[HTML][HTML] Mitotic chromosomes are self-entangled and disentangle through a topoisomerase-II-dependent two-stage exit from mitosis
EM Hildebrand, K Polovnikov, B Dekker, Y Liu… - Molecular cell, 2024 - cell.com
The topological state of chromosomes determines their mechanical properties, dynamics,
and function. Recent work indicated that interphase chromosomes are largely free of …
and function. Recent work indicated that interphase chromosomes are largely free of …
Crumpled polymer with loops recapitulates key features of chromosome organization
Chromosomes are exceedingly long topologically constrained polymers compacted in a cell
nucleus. We recently suggested that chromosomes are organized into loops by an active …
nucleus. We recently suggested that chromosomes are organized into loops by an active …
Topological and nontopological mechanisms of loop formation in chromosomes: Effects on the contact probability
K Polovnikov, B Slavov - Physical Review E, 2023 - APS
Chromosomes are crumpled polymer chains further folded into a sequence of stochastic
loops via loop extrusion. While extrusion has been verified experimentally, the particular …
loops via loop extrusion. While extrusion has been verified experimentally, the particular …
Path integrals for fractional Brownian motion and fractional Gaussian noise
Wiener's path integral plays a central role in the study of Brownian motion. Here we derive
exact path-integral representations for the more general fractional Brownian motion (FBM) …
exact path-integral representations for the more general fractional Brownian motion (FBM) …
The Rabl configuration limits topological entanglement of chromosomes in budding yeast
The three dimensional organization of genomes remains mostly unknown due to their high
degree of condensation. Biophysical studies predict that condensation promotes the …
degree of condensation. Biophysical studies predict that condensation promotes the …
Fractal polymer with loops recapitulates key features of chromosome organization
Chromosomes are exceedingly long polymers compacted in a cell nucleus. While it has long
been suggested that mammalian chromosomes during interphase are folded into loops …
been suggested that mammalian chromosomes during interphase are folded into loops …
Motorized chain models of the ideal chromosome
Z Cao, PG Wolynes - Proceedings of the National Academy of Sciences, 2024 - pnas.org
An array of motor proteins consumes chemical energy in setting up the architectures of
chromosomes. Here, we explore how the structure of ideal polymer chains is influenced by …
chromosomes. Here, we explore how the structure of ideal polymer chains is influenced by …
Mechanisms of DNA-mediated allostery
Proteins often regulate their activities via allostery—or action at a distance—in which the
binding of a ligand at one binding site influences the affinity for another ligand at a distal site …
binding of a ligand at one binding site influences the affinity for another ligand at a distal site …
Chromosome decompaction and cohesin direct Topoisomerase II activity to establish and maintain an unentangled interphase genome
EM Hildebrand, K Polovnikov, B Dekker, Y Liu… - bioRxiv, 2022 - biorxiv.org
The topological state of chromosomes is an important factor controlling their mechanical
properties, dynamics and function. Recent work has shown that interphase chromosomes …
properties, dynamics and function. Recent work has shown that interphase chromosomes …
A polymer model for the quantitative reconstruction of chromosome architecture from HiC and GAM data
It is widely believed that the folding of the chromosome in the nucleus has a major effect on
genetic expression. For example, coregulated genes in several species have been shown to …
genetic expression. For example, coregulated genes in several species have been shown to …