Neurodegenerative disorders, such as Alzheimer's disease, are a global public health
burden with poorly understood aetiology. Neuroinflammation and oxidative stress (OS) are …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal
neurodegenerative disorders that are thought to exist on a clinical and pathological …

Frontotemporal dementia (FTD) is a neurodegenerative disease of growing interest, since it
accounts for up to 10% of middle-age-onset dementias and entails a social, economic, and …

We performed hypothesis-free linkage analysis and exome sequencing in a family with two
siblings who had neuronal ceroid lipofuscinosis (NCL). Two linkage peaks with maximum …

Frontotemporal lobar degeneration (FTLD) is a clinically and pathologically heterogeneous
syndrome, characterized by progressive decline in behaviour or language associated with …

Pathogenic mutations in APP, PSEN1, PSEN2, MAPT and GRN have previously been linked
to familial early onset forms of dementia. Mutation screening in these genes has been …

We examined regional distribution patterns of phosphorylated 43-kDa TAR DNA-binding
protein (pTDP-43) intraneuronal inclusions in frontotemporal lobar degeneration (FTLD) …

Abstract Frontotemporal Lobar Degeneration (FTLD) is a clinically, pathologically and
genetically heterogeneous group of disorders that affect principally the frontal and temporal …

Alzheimer's disease (AD) is the most common cause of dementia, and its prevalence will
increase significantly in the coming decades. Although important progress has been made …

Heterozygous loss-of-function mutations in the progranulin (GRN) gene and the resulting
reduction of GRN levels is a common genetic cause for frontotemporal lobar degeneration …