The Nrf2 transcription factor governs the expression of hundreds genes involved in cell
defense against oxidative stress, the hallmark of numerous diseases such as …

Abstract The KEAP1-NRF2-ARE signaling pathway plays a central role in mediating the
adaptive cellular stress response to oxidative and electrophilic chemicals. This canonical …

Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the
cellular defense against toxic and oxidative insults through the expression of genes involved …

Myopia, also known as short-sightedness or near-sightedness, is a very common condition
that typically starts in childhood. Severe forms of myopia (pathologic myopia) are associated …

Transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of cellular responses
against environmental stresses. NRF2 induces expression of detoxification and antioxidant …

Alzheimer's disease (AD) alters astrocytes, but the effect of Aß and Tau pathology is poorly
understood. TRAP-seq translatome analysis of astrocytes in APP/PS1 ß-amyloidopathy and …

Environmental pollution is one of the most serious challenges to health in the modern world.
Pollutants alter immune responses and can provoke immunotoxicity. In this Review, we …

The Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) system
forms the major node of cellular and organismal defense against oxidative and electrophilic …

Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …

Activated hepatic stellate cells (HSCs) and myofibroblasts are the main producers of
extracellular matrix (ECM) proteins that form the fibrotic tissue that leads to hepatic fibrosis …