Indole: A privileged scaffold for the design of anti-cancer agents
Y Wan, Y Li, C Yan, M Yan, Z Tang - European journal of medicinal …, 2019 - Elsevier
In general, heterocyclic compounds are a significant source of pharmacologically active
compounds. Among them, the indole scaffold widely distributes in natural products and …
compounds. Among them, the indole scaffold widely distributes in natural products and …
Recent progress in biological activities of indole and indole alkaloids
The indole scaffold is found in a wide range of bioactive heterocycles and natural products.
Moreover, the indole moiety is considered as the active principle in several alkaloids such …
Moreover, the indole moiety is considered as the active principle in several alkaloids such …
Indole in the target-based design of anticancer agents: A versatile scaffold with diverse mechanisms
S Dadashpour, S Emami - European journal of medicinal chemistry, 2018 - Elsevier
The indole scaffold is one of the most widespread heterocycles in the naturally occurring
and synthetic bioactive compounds including anticancer agents. Due to its biodiversity and …
and synthetic bioactive compounds including anticancer agents. Due to its biodiversity and …
KLIFS: a knowledge-based structural database to navigate kinase–ligand interaction space
OPJ Van Linden, AJ Kooistra, R Leurs… - Journal of medicinal …, 2014 - ACS Publications
Protein kinases regulate the majority of signal transduction pathways in cells and have
become important targets for the development of designer drugs. We present a systematic …
become important targets for the development of designer drugs. We present a systematic …
Recent development in indole derivatives as anticancer agent: A mechanistic approach
N Devi, K Kaur, A Biharee… - Anti-Cancer Agents in …, 2021 - ingentaconnect.com
Background: Cancer accounts for several deaths each year. There are multiple FDA
approved drugs for cancer treatments. Due to the severe side effects and multiple drug …
approved drugs for cancer treatments. Due to the severe side effects and multiple drug …
Pim kinases in cancer: diagnostic, prognostic and treatment opportunities
C Blanco-Aparicio, A Carnero - Biochemical pharmacology, 2013 - Elsevier
PIM proteins belong to a family of ser/thr kinases composed of 3 members, PIM1, PIM2 and
PIM3, with greatly overlapping functions. PIM kinases are mainly responsible for cell cycle …
PIM3, with greatly overlapping functions. PIM kinases are mainly responsible for cell cycle …
PIM kinase inhibitors: Structural and pharmacological perspectives
The PIM kinase, also known as serine/threonine kinase plays an important role in cancer
biology and is found in three different isoforms namely PIM-1, PIM-2, and PIM-3. They are …
biology and is found in three different isoforms namely PIM-1, PIM-2, and PIM-3. They are …
[HTML][HTML] A small-molecule inhibitor of PIM kinases as a potential treatment for urothelial carcinomas
JM Foulks, KJ Carpenter, B Luo, Y Xu, A Senina, R Nix… - Neoplasia, 2014 - Elsevier
The proto-oncogene proviral integration site for moloney murine leukemia virus (PIM)
kinases (PIM-1, PIM-2, and PIM-3) are serine/threonine kinases that are involved in a …
kinases (PIM-1, PIM-2, and PIM-3) are serine/threonine kinases that are involved in a …
Therapeutic targeting of PIM KINASE signaling in cancer therapy: Structural and clinical prospects
Background PIM kinases are well-studied drug targets for cancer, belonging to
Serine/Threonine kinases family. They are the downstream target of various signaling …
Serine/Threonine kinases family. They are the downstream target of various signaling …
[HTML][HTML] Synthesis, in-silico studies, and biological evaluation of some novel 3-thiazolyl-indoles as CDK2–inhibitors
The essential enzyme cyclin-dependent kinase 2 (CDK2) is a promising target for anticancer
drug development due to its pivotal role in regulating the cell cycle. This study aimed to …
drug development due to its pivotal role in regulating the cell cycle. This study aimed to …