Organoids are three‐dimensional (3D) miniaturized versions of organs or tissues that are
derived from cells with stem potential and can self‐organize and differentiate into 3D cell …

Pathogenesis of viral infections of the central nervous system (CNS) is poorly understood,
and this is partly due to the limitations of currently used preclinical models. Brain organoid …

Traditionally, chemical toxicity is determined by in vivo animal studies, which are low
throughput, expensive, and sometimes fail to predict compound toxicity in humans. Due to …

Zika virus (ZIKV), belonging to the Flavivirus family and mainly transmitted by mosquitoes,
causes a variety of adverse outcomes, including Guillain-Barré syndrome, microcephaly …

Flaviviruses cause a significant amount of mortality and morbidity, especially in regions
where they are endemic. A recent example is the outbreak of Zika virus throughout the …

Zika virus (ZIKV) is a human pathogenic arbovirus. So far, neither a specific treatment nor a
vaccination against ZIKV infections has been approved. Starting from our previously …

Approaches based on animal and two-dimensional (2D) cell culture models cannot ensure
reliable results in modeling novel pathogens or in drug testing in the short term; therefore …

Brain organoids, or brainoids, have shown great promise in the study of central nervous
system (CNS) infection. Modeling Zika virus (ZIKV) infection in brain organoids may help …

Coronaviruses as possible cross-species viruses have caused several epidemics. The
ongoing emergency of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has …

Zika virus (ZIKV) infections are typically asymptomatic but cause severe neurological
complications (eg Guillain–Barré syndrome in adults, and microcephaly in newborns). There …