In eukaryotes, transcription of genes by RNA polymerase II yields messenger RNA
intermediates from which protein products are synthesized. Transcriptional enhancers are …

DNA methylation has an essential regulatory function in mammalian development, serving
to repress nontranscribed genes stably in differentiated adult somatic cells. Recent data …

The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the
remarkable progress in chromatin research over the past three years. It has been …

In eukaryotes, transcription of the diverse array of tens of thousands of protein-coding genes
is carried out by RNA polymerase II. The control of this process is predominantly mediated …

Wnt-induced formation of nuclear Tcf–β-catenin complexes promotes transcriptional
activation of target genes involved in cell fate decisions. Inappropriate expression of Tcf …

The nucleosome and chromatin fiber provide the common structural framework for
transcriptional control in eukaryotes. The folding of DNA within these structures can both …

A functional interferon-β gene enhanceosome was assembled in vitro using the purified
recombinant transcriptional activator proteins ATF2/c-JUN, IRF1, and p50/p65 of NF-κB …

Basal transcription of many genes in yeast is repressed by Mot1, an essential protein which
is a member of the Snf2/Swi2 family of conserved nuclear factors. ADI is an ATP-dependent …

The regulation of transcription requires complex interactions between proteins bound to
DNA sequences that are often separated by hundreds of base pairs. As demonstrated by a …

Enhancers are regulatory DNA sequences that activate transcription over long distances.
Recent studies revealed a widespread role of distant activation in eukaryotic gene …