Antibody-mediated neutralization of SARS-CoV-2

H Gruell, K Vanshylla, T Weber, CO Barnes, C Kreer… - Immunity, 2022 - cell.com
Neutralizing antibodies can block infection, clear pathogens, and are essential to provide
long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies …

Count on us: T cells in SARS-CoV-2 infection and vaccination

K Kedzierska, PG Thomas - Cell Reports Medicine, 2022 - cell.com
Robust T cell responses have been associated with milder outcomes in many infections. T
cells also establish long-term memory pools and, as they are predominantly directed toward …

Divergent SARS-CoV-2 Omicron–reactive T and B cell responses in COVID-19 vaccine recipients

CH GeurtsvanKessel, D Geers, KS Schmitz… - Science …, 2022 - science.org
The severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) Omicron
variant is spreading rapidly, even in vaccinated individuals, raising concerns about immune …

Omicron BA. 1 breakthrough infection drives cross-variant neutralization and memory B cell formation against conserved epitopes

J Quandt, A Muik, N Salisch, BG Lui, S Lutz… - Science …, 2022 - science.org
Omicron is the evolutionarily most distinct severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) variant of concern (VOC) to date. We report that Omicron BA. 1 breakthrough …

Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines

JE Bowen, A Addetia, HV Dang, C Stewart, JT Brown… - Science, 2022 - science.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of
concern comprises several sublineages, with BA. 2 and BA. 2.12. 1 having replaced the …

Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models

AA Cohen, N van Doremalen, AJ Greaney, H Andersen… - Science, 2022 - science.org
To combat future severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
and spillovers of SARS-like betacoronaviruses (sarbecoviruses) threatening global health …

CD8 T cells contribute to vaccine protection against SARS-CoV-2 in macaques

J Liu, J Yu, K McMahan, C Jacob-Dolan, X He… - Science …, 2022 - science.org
Spike-specific neutralizing antibodies (NAbs) are generally considered key correlates of
vaccine protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines

JE Bowen, YJ Park, C Stewart, JT Brown… - Science …, 2022 - science.org
Numerous safe and effective coronavirus disease 2019 vaccines have been developed
worldwide that use various delivery technologies and engineering strategies. We show here …

[HTML][HTML] Correlates of protection, thresholds of protection, and immunobridging among persons with SARS-CoV-2 infection

DS Khoury, TE Schlub, D Cromer, M Steain… - Emerging Infectious …, 2023 - ncbi.nlm.nih.gov
Several studies have shown that neutralizing antibody levels correlate with immune
protection from COVID-19 and have estimated the relationship between neutralizing …

Vaccine effectiveness of primary series and booster doses against covid-19 associated hospital admissions in the United States: living test negative design study

K Adams, JP Rhoads, D Surie, M Gaglani, AA Ginde… - Bmj, 2022 - bmj.com
Objective To compare the effectiveness of a primary covid-19 vaccine series plus booster
doses with a primary series alone for the prevention of hospital admission with omicron …