The sigma factors of Mycobacterium tuberculosis: regulation of the regulators

P Sachdeva, R Misra, AK Tyagi, Y Singh - The FEBS journal, 2010 - Wiley Online Library
One of the important determinants of virulence of Mycobacterium tuberculosis is adaptation
to adverse conditions encountered in the host cells. The ability of Mycobacterium to …

Mycobacterium tuberculosis transcription machinery: ready to respond to host attacks

K Flentie, AL Garner, CL Stallings - Journal of bacteriology, 2016 - Am Soc Microbiol
Regulating responses to stress is critical for all bacteria, whether they are environmental,
commensal, or pathogenic species. For pathogenic bacteria, successful colonization and …

The third pillar of bacterial signal transduction: classification of the extracytoplasmic function (ECF) σ factor protein family

A Staroń, HJ Sofia, S Dietrich, LE Ulrich… - Molecular …, 2009 - Wiley Online Library
The ability of a bacterial cell to monitor and adaptively respond to its environment is crucial
for survival. After one‐and two‐component systems, extracytoplasmic function (ECF) σ …

Defining the Transcriptional and Post-transcriptional Landscapes of Mycobacterium smegmatis in Aerobic Growth and Hypoxia

MC Martini, Y Zhou, H Sun, SS Shell - Frontiers in microbiology, 2019 - frontiersin.org
The ability of Mycobacterium tuberculosis to infect, proliferate, and survive during long
periods in the human lungs largely depends on the rigorous control of gene expression …

Validation of a Real-Time PCR for the Detection of Mycobacterium tuberculosis Complex Members in Bovine Tissue Samples

V Lorente-Leal, E Liandris, E Castellanos… - Frontiers in Veterinary …, 2019 - frontiersin.org
Although the post-mortem diagnosis of bovine tuberculosis is mainly achieved through
microbiological culture, the development of other techniques to detect Mycobacterium …

Evidence for Reductive Genome Evolution and Lateral Acquisition of Virulence Functions in Two Corynebacterium pseudotuberculosis Strains

JC Ruiz, V D'Afonseca, A Silva, A Ali, AC Pinto… - PloS one, 2011 - journals.plos.org
Background Corynebacterium pseudotuberculosi s, a Gram-positive, facultative intracellular
pathogen, is the etiologic agent of the disease known as caseous lymphadenitis (CL). CL …

Reconstruction and topological characterization of the sigma factor regulatory network of Mycobacterium tuberculosis

R Chauhan, J Ravi, P Datta, T Chen… - Nature …, 2016 - nature.com
Accessory sigma factors, which reprogram RNA polymerase to transcribe specific gene sets,
activate bacterial adaptive responses to noxious environments. Here we reconstruct the …

Comparative 'omics analyses differentiate Mycobacterium tuberculosis and Mycobacterium bovis and reveal distinct macrophage responses to infection with the …

KM Malone, K Rue-Albrecht, DA Magee… - Microbial …, 2018 - microbiologyresearch.org
Members of the Mycobacterium tuberculosis complex (MTBC) are the causative agents of
tuberculosis in a range of mammals, including humans. A key feature of MTBC pathogens is …

Sigma Factors: Key Molecules in Mycobacterium tuberculosis Physiology and Virulence

R Manganelli - Molecular genetics of mycobacteria, 2014 - Wiley Online Library
Rapid adaptation to changing environments is one of the keys of the success of
microorganisms. Such adaptation is achieved by enabling different strategies, the most …

Region of Difference 2 Contributes to Virulence of Mycobacterium tuberculosis

RA Kozak, DC Alexander, R Liao… - Infection and …, 2011 - Am Soc Microbiol
Mycobacterium bovis BCG strains are live, attenuated vaccines generated through decades
of in vitro passage. Because in vitro growth does not select for interaction with the host, it has …