Anti-cancer chalcones: Structural and molecular target perspectives

DK Mahapatra, SK Bharti, V Asati - European journal of medicinal chemistry, 2015 - Elsevier
Abstract Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold remained a fascination
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …

Synthesis and pharmacological properties of chalcones: a review

SL Gaonkar, UN Vignesh - Research on chemical intermediates, 2017 - Springer
Chalcones and their analogs have been an area of great interest in recent years. Numerous
research papers have been published, and chalcones continue to show promise for new …

Phyllanthin inhibits MOLT‐4 leukemic cancer cell growth and induces apoptosis through the inhibition of AKT and JNK signaling pathway

H Wang, A Chinnathambi, TA Alahmadi… - … of biochemical and …, 2021 - Wiley Online Library
Among cancers, leukemia is a multistep progression that involves genetic modifications of
normal hematopoietic progenitor cells to cancerous cells. In recent times, leukemia cases …

[HTML][HTML] Dietary chalcones with chemopreventive and chemotherapeutic potential

B Orlikova, D Tasdemir, F Golais, M Dicato… - Genes & nutrition, 2011 - Springer
Chalcones are absorbed in the daily diet and appear to be promising cancer
chemopreventive agents. Chalcones represent an important group of the polyphenolic …

Aptamer-conjugated and doxorubicin-loaded unimolecular micelles for targeted therapy of prostate cancer

W Xu, IA Siddiqui, M Nihal, S Pilla, K Rosenthal… - Biomaterials, 2013 - Elsevier
In the absence of effective therapy for prostate cancer, there is an immense need for
developing improved therapeutic options for the management of this disease. This study has …

Cardamonin: A new player to fight cancer via multiple cancer signaling pathways

J Nawaz, A Rasul, MA Shah, G Hussain, A Riaz… - Life sciences, 2020 - Elsevier
Nature's pharmacy has undoubtedly served humans as an affordable and safer health-care
regime for a long times. Cardamonin, a chalconoid present in several plants has been …

Boesenbergia rotunda: From Ethnomedicine to Drug Discovery

T Eng-Chong, L Yean-Kee, C Chin-Fei… - Evidence‐Based …, 2012 - Wiley Online Library
Boesenbergia rotunda is a herb from the Boesenbergia genera under the Zingiberaceae
family. B. rotunda is widely found in Asian countries where it is commonly used as a food …

[HTML][HTML] Anticancer potential of natural chalcones: in vitro and in vivo evidence

R Michalkova, L Mirossay, M Kello… - International Journal of …, 2023 - mdpi.com
There is no doubt that significant progress has been made in tumor therapy in the past
decades. However, the discovery of new molecules with potential antitumor properties still …

Molecular targeted approaches to cancer therapy and prevention using chalcones

DD Jandial, CA Blair, S Zhang, LS Krill… - Current cancer drug …, 2014 - ingentaconnect.com
There is an emerging paradigm shift in oncology that seeks to emphasize molecularly
targeted approaches for cancer prevention and therapy. Chalcones (1, 3-diphenyl-2-propen …

[HTML][HTML] Chalcones enhance TRAIL-induced apoptosis in prostate cancer cells

E Szliszka, ZP Czuba, B Mazur, L Sedek… - International journal of …, 2009 - mdpi.com
Chalcones exhibit chemopreventive and antitumor effects. Tumor necrosis factor-related
apoptosis-inducing ligand (TRAIL) is a naturally occurring anticancer agent that induces …