Cell-selective proteomics is a powerful emerging concept to study heterocellular processes
in tissues. However, its high potential to identify non-cell-autonomous disease mechanisms …

Glioblastoma (GBM) is the most prevalent and aggressive malignant primary brain tumor.
GBM proximal to the lateral ventricles (LVs) is more aggressive, potentially because of …

The recruitment of synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)
receptors underlies the strengthening of neuronal connectivity during learning and memory …

Puromycin and its derivative O-propargyl puromycin (OPP) have recently found widespread
use in detecting nascent proteins. Use of these metabolic labels in complex mixtures of cells …

Dementia is defined as the progressive decline of two or more cognitive functions that
results in a loss of quality of life. There is currently no treatment that can significantly …

Neurons dynamically regulate their proteome in response to sensory input, a key process
underlying experience-dependent plasticity. We characterized the visual experience …

Homeostatic balance between protein synthesis, turn over and degradation is vital for the
stability and viability of all living cells. The primary function of the Ubiquitin Proteasome …