[HTML][HTML] Cell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation
JJ Swietlik, S Bärthel, C Falcomatà, D Fink… - Nature …, 2023 - nature.com
Cell-selective proteomics is a powerful emerging concept to study heterocellular processes
in tissues. However, its high potential to identify non-cell-autonomous disease mechanisms …
in tissues. However, its high potential to identify non-cell-autonomous disease mechanisms …
Cell-specific cross-talk proteomics reveals cathepsin B signaling as a driver of glioblastoma malignancy near the subventricular zone
ES Norton, LA Whaley, VK Jones, MM Brooks… - Science …, 2024 - science.org
Glioblastoma (GBM) is the most prevalent and aggressive malignant primary brain tumor.
GBM proximal to the lateral ventricles (LVs) is more aggressive, potentially because of …
GBM proximal to the lateral ventricles (LVs) is more aggressive, potentially because of …
[HTML][HTML] Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis
The recruitment of synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)
receptors underlies the strengthening of neuronal connectivity during learning and memory …
receptors underlies the strengthening of neuronal connectivity during learning and memory …
[HTML][HTML] Cell type–specific labeling of newly synthesized proteins by puromycin inactivation
F Cabrera-Cabrera, H Tull, R Capuana… - Journal of Biological …, 2023 - ASBMB
Puromycin and its derivative O-propargyl puromycin (OPP) have recently found widespread
use in detecting nascent proteins. Use of these metabolic labels in complex mixtures of cells …
use in detecting nascent proteins. Use of these metabolic labels in complex mixtures of cells …
[HTML][HTML] Quantitative analysis of proteostasis networks: are there applications for dementia?
DB McClatchy - Expert Review of Proteomics, 2024 - Taylor & Francis
Dementia is defined as the progressive decline of two or more cognitive functions that
results in a loss of quality of life. There is currently no treatment that can significantly …
results in a loss of quality of life. There is currently no treatment that can significantly …
Activity-dependent synthesis of Emerin gates neuronal plasticity by regulating proteostasis
Neurons dynamically regulate their proteome in response to sensory input, a key process
underlying experience-dependent plasticity. We characterized the visual experience …
underlying experience-dependent plasticity. We characterized the visual experience …
The Ubiquitin Proteasome System as a Regulator of Neuronal Function
K Puddefoot - 2023 - figshare.le.ac.uk
Homeostatic balance between protein synthesis, turn over and degradation is vital for the
stability and viability of all living cells. The primary function of the Ubiquitin Proteasome …
stability and viability of all living cells. The primary function of the Ubiquitin Proteasome …