The biological basis of human aging remains one of the greatest unanswered scientific
questions. Increasing evidence, however, points to a role for alterations in mitochondrial …

Skeletal muscle fitness and plasticity is an important determinant of human health and
disease. Mitochondria are essential for maintaining skeletal muscle energy homeostasis by …

Importance Aging is associated with a decline in mitochondrial function and reduced
exercise capacity. Urolithin A is a natural gut microbiome–derived food metabolite that has …

Sarcopenia is the loss of muscle mass, strength, and physical function that is characteristic
of aging. The progression of sarcopenia is gradual but may be accelerated by periods of …

Patients with chronic kidney disease experience substantial loss of muscle mass, weakness,
and poor physical performance. As kidney disease progresses, skeletal muscle dysfunction …

Background The concept of mitochondrial dysfunction in ageing muscle is highly
controversial. In addition, emerging evidence suggests that reduced muscle oxidative …

This review provides a pulmonary-focused description of the age-associated changes in the
integrative physiology of exercise, including how declining lung function plays a role in …

Background 'Long COVID'describes persistent symptoms, commonly fatigue, lasting beyond
12 weeks following SARS-CoV-2 infection. Potential causes include reduced mitochondrial …

Skeletal muscle mitochondrial oxidative capacity declines with age and negatively affects
walking performance, but the mechanism for this association is not fully clear. We tested the …

Depression in later life is a severe public health problem, associated with higher rates of
mortality, suicide, and dementia. Effectiveness of treatment is limited by the failure to …