The first steps towards establishing xenografts in zebrafish embryos were performed by Lee
et al., 2005 and Haldi et al., 2006, paving the way for studying human cancers using this …

The identification of distinct waves of progenitors during development, each corresponding
to a specific time, space and function provided the basis for the concept of a “layered” …

The microbiota–gut–brain axis (MGBA) is a bidirectional signaling pathway mediating the
interaction of the microbiota, the intestine, and the central nervous system. While the MGBA …

Schizophrenia is a mental disorder that affects 1% of the population worldwide and is
manifested as a broad spectrum of symptoms, from hallucinations to memory impairment. It …

The study of heart repair post-myocardial infarction has historically focused on the
importance of cardiomyocyte proliferation as the major factor limiting adult mammalian heart …

Small guide RNA (sgRNA) is an important component of the CRISPR/Cas9 system. The
gene editing efficiency of the CRISPR/Cas9 system could be enhanced by using highly …

The goal of personalised medicine is to develop tailor-made therapies for patients in whom
currently available therapeutics fail. This approach requires correlating individual patient …

Characterization of the clustered, regularly interspaced, short, palindromic repeat (CRISPR)
system of Streptococcus pyogenes has enabled the development of a customizable platform …

Signal transducer and activator of transcription (STAT) proteins act downstream of cytokine
receptors to facilitate changes in gene expression that impact a range of developmental and …

The use of zebrafish in functional genomics and disease modeling has become popular due
to the ease of targeted mutagenesis with genome editing nucleases, ie, zinc finger …