Targeting CK2 in cancer: a valuable strategy or a waste of time?
CK2 is a protein kinase involved in several human diseases (ranging from neurological and
cardiovascular diseases to autoimmune disorders, diabetes, and infections, including …
cardiovascular diseases to autoimmune disorders, diabetes, and infections, including …
Emerging Therapies for Glioblastoma
SA Rios, S Oyervides, D Uribe, AM Reyes, V Fanniel… - Cancers, 2024 - mdpi.com
Simple Summary Glioblastoma is the most common malignant brain cancer and is
associated with poor prognosis, with an average survival after diagnosis of less than 18 …
associated with poor prognosis, with an average survival after diagnosis of less than 18 …
Analysis of the phosphoproteome of CK2α(–/–)/Δα′ C2C12 myoblasts compared to the wild-type cells
CK2 is a Ser/Thr protein kinase composed of two catalytic (α/α′) subunits and a non-
catalytic β-subunit dimer, whose activity is often abnormally high in cancer cells. The …
catalytic β-subunit dimer, whose activity is often abnormally high in cancer cells. The …
CX-4945 inhibits fibroblast-like synoviocytes functions through the CK2-p53 axis to reduce rheumatoid arthritis disease severity
Y Luo, Y Lei, X Guo, D Zhu, H Zhang, Z Guo… - International …, 2023 - Elsevier
Fibroblast-like synoviocytes (FLS) mediate many pathological processes in rheumatoid
arthritis (RA), including pannus formation, bone erosion, and inflammation. RA FLS have …
arthritis (RA), including pannus formation, bone erosion, and inflammation. RA FLS have …
A comprehensive review on the dynamics of protein kinase CK2 in cancer development and optimizing therapeutic strategies
MU Ghani, J Shi, Y Du, L Zhong, H Cui - International Journal of Biological …, 2024 - Elsevier
Abstract Protein kinase 2 (CK2) is an enzyme ubiquitously present and exhibits extensive
kinase activity. It has been strongly linked to tumor progression through the abnormal …
kinase activity. It has been strongly linked to tumor progression through the abnormal …
HMGA1, moonlighting protein function, and cellular real estate: location, location, location!
M Pujals, L Resar, J Villanueva - Biomolecules, 2021 - mdpi.com
The gene encoding the High Mobility Group A1 (HMGA1) chromatin remodeling protein is
upregulated in diverse cancers where high levels portend adverse clinical outcomes. Until …
upregulated in diverse cancers where high levels portend adverse clinical outcomes. Until …
Integrated Analysis of Multiomics Data Identified Molecular Subtypes and Oxidative Stress‐Related Prognostic Biomarkers in Glioblastoma Multiforme
Y Ma, Z Xi - Oxidative Medicine and Cellular Longevity, 2022 - Wiley Online Library
Glioblastoma multiforme (GBM) is a glioma in IV stage, which is one of the most common
primary malignant brain tumors in adults. GBM has the characters of high invasiveness, high …
primary malignant brain tumors in adults. GBM has the characters of high invasiveness, high …
C-Myc/H19/miR-29b axis downregulates nerve/glial (NG) 2 expression in glioblastoma multiforme
AS Boewe, S Wrublewsky, J Hoppstädter… - … Therapy-Nucleic Acids, 2024 - cell.com
Nerve/glial antigen (NG) 2 is highly expressed in glioblastoma multiforme (GBM). However,
the underlying mechanisms of its upregulated expression are largely unknown. In silico …
the underlying mechanisms of its upregulated expression are largely unknown. In silico …
Inhibition of CK2 Reduces NG2 Expression in Juvenile Angiofibroma
AS Boewe, S Wemmert, P Kulas, B Schick, C Götz… - Biomedicines, 2022 - mdpi.com
Juvenile angiofibroma (JA) is a rare fibrovascular neoplasm predominately found within the
posterior nasal cavity of adolescent males. JA expresses the proteoglycan nerve–glial …
posterior nasal cavity of adolescent males. JA expresses the proteoglycan nerve–glial …
Novel treatment strategies for glioblastoma—A summary
SS Stylli - Cancers, 2021 - mdpi.com
Glioblastoma (GBM) is the most common primary central nervous system tumor in adults,
accounting for approximately 80% of all brain-related malignancies [1]. It is a highly invasive …
accounting for approximately 80% of all brain-related malignancies [1]. It is a highly invasive …