The complement system was discovered at the end of the 19th century as a heat-labile
plasma component that “complemented” the antibodies in killing microbes, hence the name …

Complement is an important component of the innate immune system that is crucial for
defense from microbial infections and for clearance of immune complexes and injured cells …

A biomarker can be a substance or structure measured in body parts, fluids or products that
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …

The human newborn infant is susceptible to gut inflammatory disorders. In particular, growth-
restricted infants or infants born prematurely may develop a severe form of intestinal …

The complement system is an evolutionarily ancient key component of innate immunity
required for the detection and removal of invading pathogens. It was discovered more than …

Inflammation is associated with development of atherosclerosis, and cholesterol crystals
(CC) have long been recognized as a hallmark of atherosclerotic lesions. CC appear early …

Traumatic brain injury (TBI) is an important cause of disability and mortality in the western
world. While the initial injury sustained results in damage, it is the subsequent secondary …

Activation of the complement system is a major pathogenic event that drives various
inflammatory responses in numerous diseases. All pathways of complement activation lead …

Complement activation generates the core effector protein C5a, a potent immune molecule
that is linked to multiple inflammatory diseases. Two C5a receptors, C5aR1 (C5aR, CD88) …

Age-related macular degeneration (AMD) is an inflammatory disease, which causes visual
impairment and blindness in older people. The proteins of the complement system are …