The metabolic syndrome affects 30% of the US population with increasing prevalence. In
this paper, we explore the relationship between the metabolic syndrome and the incidence …

Myocardial stretch elicits a rapid increase in developed force, which is mainly caused by an
increase in myofilament calcium sensitivity (Frank-Starling mechanism). Over the ensuing 10 …

Rationale: The cellular and molecular basis for post–myocardial infarction (MI) structural and
functional remodeling is not well understood. Objective: Our aim was to determine if Ca2+ …

Objectives: This study sought to ascertain whether high-dose allopurinol causes regression
of left ventricular mass (LVM) in patients with type 2 diabetes mellitus (T2DM). Background …

Nearly 40 years ago, the Sagawa laboratory spawned a renaissance in the use of
instantaneous ventricular pressure-volume (PV) relations to assess cardiac function. Since …

Background Right ventricular (RV) failure due to increased pressure load causes significant
morbidity and mortality in patients with congenital heart diseases and pulmonary arterial …

Reactive oxygen species (ROS) exert signaling character (redox signaling), or damaging
character (oxidative stress) on cardiac tissue depending on their concentration and/or …

Background/Aims: The serum-and glucocorticoid-inducible kinase Sgk1 contributes to
cardiac remodeling and development of heart failure, which is paralelled by Sgk1 …

This review summarizes and describes the current evidence addressing how sodium-
glucose cotransporter 2 (SGLT2) inhibitors alter the function of sodium-hydrogen exchanger …

BACKGROUND The association between serum uric acid (SUA) and left ventricular
hypertrophy (LVH) is controversial and the ability of SUA in predicting incident LVH remains …