The solute carrier family 12 (SLC12) of cation-chloride cotransporters (CCCs) comprises
potassium chloride cotransporters (KCCs, eg KCC1, KCC2, KCC3, and KCC4)-mediated …

The incidence of metabolic diseases—hypertension, diabetes, obesity, metabolic
dysfunction-associated steatotic liver disease (MASLD), and atherosclerosis—is increasing …

The sodium-chloride cotransporter NCC mediates the coupled import of sodium and
chloride across the plasma membrane, playing vital roles in kidney extracellular fluid volume …

Perturbation of solute carriers (SLCs) has been implicated in metabolic disorders and
cancer, highlighting the potential for drug discovery and therapeutic opportunities. However …

Salinity is a critical abiotic factor for all living organisms. The ability to adapt to different
salinity environments determines an organism's survival and ecological niches. Litoditis …

The intracellular concentration of chloride anions ([Cl–] i), the equilibrium potential for
chloride anions (ECl), and transmembrane chloride currents (ICl) are significant factors …

Cl− is a major anion in the bodily fluids of vertebrates, and maintaining its homeostasis is
essential for normal physiological functions. Fishes inhabiting freshwater (FW) passively …

Background Glioma is one of the most common malignant brain tumors. It has a high rate of
progression and a poor prognosis, and effective biomarkers still need to be identified. The …

Intracellular chloride levels in the brain are regulated primarily through the opposing effects
of two cation-chloride co-transporters (CCCs), namely K+-Cl− co-transporter-2 (KCC2) and …

Cardiovascular diseases, the leading life-threatening conditions, involve cardiac arrhythmia,
coronary artery disease, myocardial infarction, heart failure, cardiomyopathy, and heart …