Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …

Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell
death and programmed apoptotic, and are crucial for cell metabolism and survival …

Aging is a complex process that results in loss of the ability to reattain homeostasis following
stress, leading, thereby, to increased risk of morbidity and mortality. Many factors contribute …

The routine and often unavoidable exposure to solar ultraviolet (UV) radiation makes it one
of the most significant environmental DNA-damaging agents to which humans are exposed …

Aging in mammals is accompanied by a progressive atrophy of tissues and organs, and
stochastic damage accumulation to the macromolecules DNA, RNA, proteins, and lipids …

The skin is a high turnover organ, and its constant renewal depends on the rapid
proliferation of its progenitor cells. The energy requirement for these metabolically active …

Mitochondrial dysfunction is a common feature in neurodegeneration and aging. We identify
mitochondrial dysfunction in xeroderma pigmentosum group A (XPA), a nucleotide excision …

DNA damage created by endogenous or exogenous genotoxic agents can exist in multiple
forms, and if allowed to persist, can promote genome instability and directly lead to various …

Mitochondrial dysfunction is a hallmark of ageing, and mitochondrial maintenance may lead
to increased healthspan. Emerging evidence suggests a crucial role for signalling from the …

Aging is an inevitable process of life. Defined by progressive physiological and functional
loss of tissues and organs, aging increases the risk of mortality for the organism. The aging …