Acetals and ketals and their nitrogen and sulfur homologues are often considered to be
unconventional and potentially problematic scaffolding elements or pharmacophores for the …

The virally encoded protease is an important drug target for AIDS therapy. Despite the
potency of the current drugs, infections with resistant viral strains limit the long-term …

Chikungunya virus (CHIKV) causes a febrile disease associated with chronic arthralgia,
which may progress to neurological impairment. Chikungunya fever (CF) is an ongoing …

Highly enantioselective and chemodivergent domino reactions between γ-substituted
allenoates and activated alkenes have been developed. In the presence of NUSIOC-Phos …

HIV-1 protease is an important target for the development of antiviral inhibitors to treat AIDS.
A room-temperature joint X-ray/neutron structure of the protease in complex with clinical …

The design, synthesis, and biological evaluation of a series of HIV-1 protease inhibitors
incorporating stereochemically defined fused tricyclic P2 ligands are described. Various …

The influenza virus causes acute respiratory infections, leading to high morbidity and
mortality in groups of patients at higher risk. Antiviral drugs represent the first line of defense …

Drug resistance of mutations in HIV-1 protease (PR) is the most severe challenge to the long-
term efficacy of HIV-1 PR inhibitor in highly active antiretroviral therapy. To elucidate the …

Four HIV-1 protease (PR) inhibitors, clinical inhibitors lopinavir and tipranavir, and two
investigational compounds 4 and 5, were studied for their effect on the structure and activity …

Extreme drug resistant mutant of HIV-1 protease (PR) bearing 20 mutations (PR20) has
been studied with the clinical inhibitor amprenavir (1) and two potent antiviral investigational …