[HTML][HTML] Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of nonalcoholic fatty liver disease (NAFLD)
YY Qiu, J Zhang, FY Zeng, YZ Zhu - Pharmacological Research, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of disease phenotypes
which start with simple steatosis and lipid accumulation in the hepatocytes-a typical …
which start with simple steatosis and lipid accumulation in the hepatocytes-a typical …
[HTML][HTML] Type 2 diabetes and cardiovascular disease: have all risk factors the same strength?
I Martín-Timón, C Sevillano-Collantes… - World journal of …, 2014 - ncbi.nlm.nih.gov
Diabetes mellitus is a chronic condition that occurs when the body cannot produce enough
or effectively use of insulin. Compared with individuals without diabetes, patients with type 2 …
or effectively use of insulin. Compared with individuals without diabetes, patients with type 2 …
Inflammation and metabolic disorders
GS Hotamisligil - Nature, 2006 - nature.com
Metabolic and immune systems are among the most fundamental requirements for survival.
Many metabolic and immune response pathways or nutrient-and pathogen-sensing systems …
Many metabolic and immune response pathways or nutrient-and pathogen-sensing systems …
Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
Highly potent, but poorly water-soluble, drug candidates are common outcomes of
contemporary drug discovery programmes and present a number of challenges to drug …
contemporary drug discovery programmes and present a number of challenges to drug …
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
In obesity and type 2 diabetes, expression of the GLUT4 glucose transporter is decreased
selectively in adipocytes. Adipose-specific Glut4 (also known as Slc2a4) knockout (adipose …
selectively in adipocytes. Adipose-specific Glut4 (also known as Slc2a4) knockout (adipose …
A critical assessment of docking programs and scoring functions
GL Warren, CW Andrews, AM Capelli… - Journal of medicinal …, 2006 - ACS Publications
Docking is a computational technique that samples conformations of small molecules in
protein binding sites; scoring functions are used to assess which of these conformations best …
protein binding sites; scoring functions are used to assess which of these conformations best …
Regulation of catalase expression in healthy and cancerous cells
C Glorieux, M Zamocky, JM Sandoval, J Verrax… - Free Radical Biology …, 2015 - Elsevier
Catalase is an important antioxidant enzyme that dismutates hydrogen peroxide into water
and molecular oxygen. The catalase gene has all the characteristics of a housekeeping …
and molecular oxygen. The catalase gene has all the characteristics of a housekeeping …
[HTML][HTML] Alternative M2 activation of Kupffer cells by PPARδ ameliorates obesity-induced insulin resistance
JI Odegaard, RR Ricardo-Gonzalez, AR Eagle, D Vats… - Cell metabolism, 2008 - cell.com
Macrophage infiltration and activation in metabolic tissues underlie obesity-induced insulin
resistance and type 2 diabetes. While inflammatory activation of resident hepatic …
resistance and type 2 diabetes. While inflammatory activation of resident hepatic …
The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity
P Ferré - Diabetes, 2004 - Am Diabetes Assoc
Peroxisome proliferator-activated receptors (PPARs) are transcription factors belonging to
the superfamily of nuclear receptors. Three isoforms (α, δ, and γ) have been described. They …
the superfamily of nuclear receptors. Three isoforms (α, δ, and γ) have been described. They …
Pathways of polyunsaturated fatty acid utilization: implications for brain function in neuropsychiatric health and disease
JJ Liu, P Green, JJ Mann, SI Rapoport, ME Sublette - Brain research, 2015 - Elsevier
Essential polyunsaturated fatty acids (PUFAs) have profound effects on brain development
and function. Abnormalities of PUFA status have been implicated in neuropsychiatric …
and function. Abnormalities of PUFA status have been implicated in neuropsychiatric …