Strategies for optimizing the production of proteins and peptides with multiple disulfide bonds

Y Ma, CJ Lee, JS Park - Antibiotics, 2020 - mdpi.com
Bacteria can produce recombinant proteins quickly and cost effectively. However, their
physiological properties limit their use for the production of proteins in their native form …

Artesunate, as a HSP70 ATPase activity inhibitor, induces apoptosis in breast cancer cells

M Pirali, M Taheri, S Zarei, M Majidi… - International Journal of …, 2020 - Elsevier
The present study aims to evaluate the inhibitory effects of artesunate (a semi-synthetic
derivative of artemisinin) on HSP70 and Bcl-2 expression in two breast cancer cell lines, 4T1 …

Nanozyme‐incorporated Microneedles for the Treatment of Chronic Wounds

Z Hu, J Shan, Y Cui, L Cheng… - Advanced Healthcare …, 2024 - Wiley Online Library
Acute wounds are converted to chronic wounds due to advanced age and diabetic
complications. Nanoenzymes catalyze ROS production to kill bacteria without causing drug …

NIR‐Triggered Multifunctional NO Nanoplatform for Conquering Thermal Resistance in Biofilms

B Zhou, B Dong, S Hu, W Liu, L Sun, L Xu, X Bai… - Small, 2024 - Wiley Online Library
Photothermal treatment (PTT) has emerged as a promising avenue for biofilm elimination,
yet its potential drawbacks, such as local hyperpyrexia and bacterial heat resistance, have …

Polyphyllin D-loaded solid lipid nanoparticles for breast cancer: Synthesis, characterization, in vitro, and in vivo studies

A Emami, H Ghafouri, R Sariri - International Journal of Pharmaceutics, 2023 - Elsevier
Polyphyllin D (PD), a steroidal saponin in Paris polyphylla, induces apoptosis via the
intrinsic apoptotic pathway in different cancer types. However, emerging evidence has …

Disrupting the protein-protein interaction network of Hsp72 inhibits adipogenic differentiation and lipid synthesis in adipocytes

YT Hu, YW Lin, SY Guo, Z Jiang, SM Xu, Z Su… - Cellular …, 2024 - Elsevier
The biological function against obesity of heat shock protein Hsp72 in adipose tissue has
remained unclear. Our findings demonstrated that the expression levels of Hsp72 increased …

Synthesis, in vitro biological evaluation and molecular modelling of new 2-chloro-3-hydrazinopyrazine derivatives as potent acetylcholinesterase inhibitors‏ on PC12 …

M Taheri, S Aslani, H Ghafouri, A Mohammadi… - BMC chemistry, 2022 - Springer
Background The loss of cholinergic neurotransmission in Alzheimer's disease (AD) patients'
brain is accompanied by a reduced concentration of Acetylcholine (ACh) within synaptic …

A novel sulfamethoxazole derivative as an inhibitory agent against HSP70: A combination of computational with in vitro studies

VA Moghaddam, V Kasmaeifar, Z Mahmoodi… - International Journal of …, 2021 - Elsevier
In the current study, a novel derivative of sulfamethoxazole (a sulfonamide containing anti-
biotic) named ZM-093 (IUPAC name:(E)-4-((4-(bis (2-hydroxyethyl) amino) phenyl) diazenyl) …

EGFR-mediated HSP70 phosphorylation facilitates PCNA association with chromatin and DNA replication

Y Wang, A Fernandez, X Pei, B Liu, L Shen… - Nucleic Acids …, 2024 - academic.oup.com
Efficient DNA replication requires highly coordinated programs for the timely recruitment of
protein complexes to DNA replication forks. Defects in this process result in replication …

[PDF][PDF] 热休克蛋白70: 生物学功能与作用机制研究进展

樊欣, 彭仁 - 生命科学, 2019 - lifescience.sinh.ac.cn
热休克蛋白是一类广泛存在于原核生物和真核生物体内且结构上高度保守的蛋白质.
有机体在应激条件下, 为克服压力会诱导其表达, 因此, 热休克蛋白又被称为应激蛋白 …