Pathophysiology of delayed cerebral ischemia after subarachnoid hemorrhage: a review
Delayed cerebral ischemia is a major predictor of poor outcomes in patients who suffer
subarachnoid hemorrhage. Treatment options are limited and often ineffective despite many …
subarachnoid hemorrhage. Treatment options are limited and often ineffective despite many …
Spreading depression, spreading depolarizations, and the cerebral vasculature
C Ayata, M Lauritzen - Physiological reviews, 2015 - journals.physiology.org
Spreading depression (SD) is a transient wave of near-complete neuronal and glial
depolarization associated with massive transmembrane ionic and water shifts. It is …
depolarization associated with massive transmembrane ionic and water shifts. It is …
Cerebrospinal fluid influx drives acute ischemic tissue swelling
INTRODUCTION Cerebrospinal fluid (CSF) covers and protects the brain from mechanical
injury. CSF also flows along an interconnected network of perivascular spaces surrounding …
injury. CSF also flows along an interconnected network of perivascular spaces surrounding …
The continuum of spreading depolarizations in acute cortical lesion development: examining Leao's legacy
JA Hartings, CW Shuttleworth… - Journal of Cerebral …, 2017 - journals.sagepub.com
A modern understanding of how cerebral cortical lesions develop after acute brain injury is
based on Aristides Leão's historic discoveries of spreading depression and asphyxial/anoxic …
based on Aristides Leão's historic discoveries of spreading depression and asphyxial/anoxic …
Spreading depolarizations in ischaemia after subarachnoid haemorrhage, a diagnostic phase III study
JP Dreier, MKL Winkler, S Major, V Horst, S Lublinsky… - Brain, 2022 - academic.oup.com
Focal brain damage after aneurysmal subarachnoid haemorrhage predominantly results
from intracerebral haemorrhage, and early and delayed cerebral ischaemia. The …
from intracerebral haemorrhage, and early and delayed cerebral ischaemia. The …
Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: review and recommendations of the COSBID research group
JP Dreier, M Fabricius, C Ayata… - Journal of Cerebral …, 2017 - journals.sagepub.com
Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal
transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable …
transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable …
The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease
JP Dreier - Nature medicine, 2011 - nature.com
The term spreading depolarization describes a wave in the gray matter of the central
nervous system characterized by swelling of neurons, distortion of dendritic spines, a large …
nervous system characterized by swelling of neurons, distortion of dendritic spines, a large …
The importance of early brain injury after subarachnoid hemorrhage
Aneurysmal subarachnoid hemorrhage (aSAH) is a medical emergency that accounts for
5% of all stroke cases. Individuals affected are typically in the prime of their lives (mean age …
5% of all stroke cases. Individuals affected are typically in the prime of their lives (mean age …
Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic …
M Lauritzen, JP Dreier, M Fabricius… - Journal of Cerebral …, 2011 - journals.sagepub.com
Cortical spreading depression (CSD) and depolarization waves are associated with
dramatic failure of brain ion homeostasis, efflux of excitatory amino acids from nerve cells …
dramatic failure of brain ion homeostasis, efflux of excitatory amino acids from nerve cells …
Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations
D Pietrobon, MA Moskowitz - Nature Reviews Neuroscience, 2014 - nature.com
Punctuated episodes of spreading depolarizations erupt in the brain, encumbering tissue
structure and function, and raising fascinating unanswered questions concerning their …
structure and function, and raising fascinating unanswered questions concerning their …