Breakdown of cellular membranes is a characteristic feature of neuronal degeneration in
acute (stroke) and chronic (senile dementia) neurological disorders. The present review …

Molecular identification of the genes and resulting protein sequences for a large number of
nicotinic acetylcholine receptor (nAChR) subunits has stimulated numerous studies …

This study assessed the choline status in newborns, infants, children, breast-feeding
women, breast milk, infant formula, breast-fed and formula-fed infants. The serum free …

Objective.—To test the hypothesis that uptake of circulating choline into the brain decreases
with age, because alterations in metabolism of choline may be a factor contributing to age …

Knock-in mice were generated that harbored a leucine-to-serine mutation in the α4 nicotinic
receptor near the gate in the channel pore. Mice with intact expression of this hypersensitive …

Experimental and clinical studies give evidence for breakdown of membrane phospholipids
during neurodegeneration. In the present study, we measured the levels of …

New brain synapses form when a postsynaptic structure, the dendritic spine, interacts with a
presynaptic terminal. Brain synapses and dendritic spines, membrane-rich structures, are …

Background: The frontal lobe has been implicated in the pathology of depression in adults.
Through the use of magnetic resonance spectroscopy, altered brain choline levels have also …

OBJECTIVE: An extra portion of chromosome 21 in Down's syndrome leads to a dementia in
later life that is phenotypically similar to Alzheimer's disease. Down's syndrome therefore …

Choline participates in several relevant neurochemical processes. It is the precursor and
metabolite of acetylcholine (ACh), plays a role in single-carbon metabolism and is an …