All causes of renal allograft injury, when severe and/or sustained, can result in chronic
histological damage of which interstitial fibrosis and tubular atrophy are dominant features …

Protocol renal allograft biopsies at fixed time points from transplantation have aided
research and provided insights into the pathogenesis of early and late allograft injury. Their …

Many complications after renal transplantation can be prevented if they are detected early.
Guidelines have been developed for the prevention of diseases in the general population …

The pathogenesis of chronic renal allograft rejection (CR) remains obscure. The hypothesis
that a subset of CR is mediated by antidonor antibody was tested by determining whether …

Chronic allograft nephropathy (CAN) in protocol biopsies is associated with graft loss while
the association between subclinical rejection (SCR) and outcome has yielded contradictory …

We conducted a randomized, multicenter study to determine whether treatment of subclinical
rejection with increased corticosteroids resulted in beneficial outcomes in renal transplant …

Chronic allograft nephropathy (CAN) is due to both immunologic and non-immunologic
factors and results in the development of nonspecific pathologic features that may even be …

Risk factors for chronic allograft nephropathy after renal transplantation: A protocol biopsy
study. Background Chronic allograft nephropathy (CAN) leads to chronic allograft …

Graft function and histology are predictive of renal transplant survival. The Rapamune
Maintenance Regimen study demonstrated that early cyclosporine (CsA) withdrawal from a …

Interstitial fibrosis and tubular atrophy (IFTA) is found in approximately 25% of 1‐year
biopsies posttransplant. It is known that IFTA correlates with decreased graft survival when …