Sleep is an essential physiological function that sustains human life. Sleep disorders involve
problems with the quality, duration, and abnormal behaviour of sleep. Insomnia is the most …

Introduction Recent studies indicate that Alzheimer's disease-(AD) related biomarkers,
including amyloid β (Aβ40 and Aβ42) and tau proteins (P-tau and T-tau), in blood and …

Oxygen metabolism abnormality plays a crucial role in the pathogenesis of Alzheimer's
disease (AD) via several mechanisms, including hypoxia, oxidative stress, and …

Sleep disorders are becoming increasingly common, and their distinct effects on physical
and mental health require elaborate investigation. Gut dysbiosis (GD) has been reported in …

Chronic hypoxia is a risk factor for Alzheimer's disease (AD), and the neurofibrillary tangle
(NFT) formed by hyperphosphorylated tau is one of the two major pathological changes in …

Voluntary asphyxia imposed by static apnea challenges blood-brain barrier (BBB) integrity
in humans through transient extremes of hypertension, hypoxemia and hypercapnia. In the …

Human environment is highly contaminated with aluminum, and aluminum is toxic to
majority of tissues, particularly to neurons. In previous decades, aluminum exposure was …

Tauopathies are a group of neurodegenerative diseases whose central feature is
dysfunction of the microtubule-associated protein tau (MAPT). Although the exact etiology of …

Background Chronic intermittent hypoxia (CIH) could cause neuronal damage, accelerating
the progression of dementia. However, safe and effective therapeutic drugs and delivery are …

Intermittent hypoxia is the best predictor of developing cognitive decline and Alzheimer's
disease progression in patients with obstructive sleep apnea. The nucleotide-binding …