Nonsteroidal antiinflammatory drugs (NSAIDs) appear to reduce the risk of developing
cancer. One mechanism through which NSAIDs act to reduce carcinogenesis is to inhibit the …

Abstract Cyclooxygenase‐2 (COX‐2) is the inducible isoform of cyclooxygenase, the
enzyme that catalyzes the rate‐limiting step in prostaglandin synthesis from arachidonic …

Context Aspirin reduces risk of colorectal neoplasia in randomized trials and inhibits tumor
growth and metastases in animal models. However, the influence of aspirin on survival after …

The liver is host to many metastatic cancers, particularly colorectal cancer, for which the last
2 decades have seen major advances in diagnosis and treatment. The liver is a vital organ …

The aim of this study was to assess the efficacy human mesenchymal stem cells (hMSC) for
targeting microscopic tumors and suicide gene or cytokine gene therapy. Immunodeficient …

In addition to the well-established pathophysiological role that COX-2 plays in inflammation,
recent evidence implies that this isoform may also be involved in multiple biologic events …

The aggressive biology of human pancreatic adenocarcinoma has been linked with
overexpression of vascular endothelial growth factor (VEGF). Constitutive activation of the …

Background: The preventive role of non-steroid anti-inflammatory drugs (NSAIDs) and
aspirin, in particular, on colorectal cancer is well established. More recently, it has been …

Prostaglandin E2 (PGE2), a major COX metabolite, plays important roles in several facets of
tumor biology. We characterized the contribution of the PGE2 EP2 receptor to cancer …

Cancer initiation and progression are multistep events that require cell proliferation,
migration, extravasation to the blood or lymphatic vessels, arrest to the metastatic site, and …