Peripheral neuropathy is one of the most common complications of both type 1 and type 2
diabetes. Up to half of patients with diabetes develop neuropathy during the course of their …

Discovered more than 30 years ago, the angiotensin AT 2 receptor (AT 2 R) has evolved
from a binding site with unknown function to a firmly established major effector within the …

Next-generation transcriptomics in combination with imaging-based approaches have
emerged as powerful tools for the characterization of dorsal root ganglion (DRG) neuronal …

Pain is the primary motivation for seeking medical care. Although pain may subside as
inflammation resolves or an injury heals, it is increasingly evident that persistency of the pain …

Sensory neurons located in dorsal root ganglia (DRG) convey sensory information from
peripheral tissue to the brain. After peripheral nerve injury, sensory neurons switch to a …

Cross-talk between peripheral neurons and immune cells is important in pain sensation. We
identified Snx25 as a pain-modulating gene in a transgenic mouse line with reduced pain …

Neurodegenerative disorders, including chemotherapy-induced cognitive impairment, are
associated with neuronal mitochondrial dysfunction. Cisplatin, a commonly used …

Peripheral nerve damage initiates a complex series of structural and cellular processes that
culminate in chronic neuropathic pain. The recent success of a type 2 angiotensin II (Ang II) …

The topic of this chapter, transient receptor potential ankyrin 1 (TRPA1), is a calcium-
permeable nonselective cation channel that is a member of the TRP family expressed on …

Dorsal root ganglion (DRG) neurons detect sensory inputs and are crucial for pain
processing. They are often studied in vitro as dissociated cell cultures with the assumption …