The blood-brain barrier (BBB) is involved in the pathogenesis of Alzheimer's disease (AD).
BBB is a highly selective semipermeable structural and chemical barrier which ensures a …

Icariin (ICA) is a principal active component from traditional Chinese medicine Epimedium
grandiflorum. To explain its traditional medical usages by modern science, a variety of …

Disease heterogeneity has been a critical challenge for precision diagnosis and treatment,
especially in neurologic and neuropsychiatric diseases. Many diseases can display multiple …

Stroke and Alzheimer's disease (AD) are cerebral pathologies with high socioeconomic
impact that can occur together and mutually interact. Vascular factors predisposing to …

Central nervous system (CNS) accumulation of fibrillary deposits made of Amyloid β (A β),
hyperphosphorylated Tau or α-synuclein (α-syn), present either alone or in the form of mixed …

Hypoxia is a state of reduced oxygen supply and excessive oxygen consumption. According
to the duration of hypoxic period, it can be classified as acute and chronic hypoxia. Both …

Finding effective disease‐modifying treatment for Alzheimer's disease remains challenging
due to an array of factors contributing to the loss of neural function. The current study …

Icariin is a major active component of the traditional herb Epimedium, also known as Horny
Goat Weed. It has been extensively studied throughout the past several years and is known …

Amyloidogenicity and vascular dysfunction are the key players in the pathogenesis of
Alzheimer's disease (AD), involving dysregulated cellular interactions. An intricate balance …

Continuing efforts from large international consortia have made genome-wide epigenomic
and transcriptomic annotation data publicly available for a variety of cell and tissue types …