Simple Summary Scientists use animal models to study the mechanisms of human diseases
and find new drugs to treat them. Chronic Unpredictable Mild Stress is the best animal …

The hypothalamic–pituitary–adrenal (HPA) axis regulates the secretion of glucocorticoids,
hormones with diverse roles ranging from regulating daily metabolic demand to coping with …

The field of psychoneuroimmunology has advanced the understanding of the relationship
between immunology and mental health. More work can be done to advance the field by …

Maternal infection during pregnancy may increase the risk of offspring neurodevelopmental
disorders. The preclinical Polyinosinic-polycytidylic acid (PolyIC) model has become one of …

Abstract A 28-kDa polysaccharide-peptide (PGL) with antidepressant-like activities was
isolated from spores of the mushroom Ganoderma lucidum. It was unadsorbed on DEAE …

Chronic stress plays a key role in inducing various clinical disorders through mechanistic
pathways, including oxidative stress and apoptosis. Transient receptor potential vanilloid 1 …

The mission of the National Institute of Mental Health is to transform the understanding and
treatment of mental illnesses through basic and clinical research, paving the way for …

Background: This study investigated the effects of fish oil and olive oil in improving dysbiosis
and depressive-like symptoms. Methods and results: Male rats were fed normal, fish oil-rich …

Non-specific low back pain (LBP) is a major global disease burden and childhood adversity
predisposes to its development. The mechanisms are largely unknown. Here, we …

Introduction: Achillea tenuifolia Lam (AT) has several biological activities and medicinal
properties. In this study, we elucidated the impact of the AT on anxiety-related behaviors …