Homozygous familial hypercholesterolemia
A Nohara, H Tada, M Ogura, S Okazaki… - … of atherosclerosis and …, 2021 - jstage.jst.go.jp
Familial hypercholesterolemia (FH) is an inherited disorder with retarded clearance of
plasma LDL caused by mutations of the genes involved in the LDL receptor-mediated …
plasma LDL caused by mutations of the genes involved in the LDL receptor-mediated …
Familial hypercholesterolemia treatments: Guidelines and new therapies
Familial hypercholesterolemia (FH) is a genetic disorder resulting from mutations in genes
encoding proteins involved in the metabolism of low density lipoproteins (LDL) and …
encoding proteins involved in the metabolism of low density lipoproteins (LDL) and …
Guidelines for the diagnosis and treatment of pediatric familial hypercholesterolemia 2022
M Harada-Shiba, A Ohtake, D Sugiyama… - … of atherosclerosis and …, 2023 - jstage.jst.go.jp
As atherosclerosis begins in childhood, early diagnosis and treatment of familial
hypercholesterolemia (FH) is considered necessary. The basic diagnosis of pediatric FH …
hypercholesterolemia (FH) is considered necessary. The basic diagnosis of pediatric FH …
Familial hypercholesterolaemia
JC Defesche, SS Gidding, M Harada-Shiba… - Nature reviews Disease …, 2017 - nature.com
Familial hypercholesterolaemia is a common inherited disorder characterized by abnormally
elevated serum levels of low-density lipoprotein (LDL) cholesterol from birth, which in time …
elevated serum levels of low-density lipoprotein (LDL) cholesterol from birth, which in time …
Familial hypercholesterolaemia: evolving knowledge for designing adaptive models of care
GF Watts, SS Gidding, P Mata, J Pang… - Nature Reviews …, 2020 - nature.com
Optimal care for familial hypercholesterolaemia (FH) requires patient-centred management,
multidisciplinary teamwork, involvement of primary care practitioners, patient networks …
multidisciplinary teamwork, involvement of primary care practitioners, patient networks …
Japan Atherosclerosis Society (JAS) Guidelines for prevention of atherosclerotic cardiovascular diseases 2022
T Okamura, K Tsukamoto, H Arai, Y Fujioka… - … of Atherosclerosis and …, 2024 - jstage.jst.go.jp
In Japan, a super-aged society, deaths from atherosclerotic cardiovascular disease
(ASCVD), especially cardiac diseases including coronary artery disease (CAD) such as …
(ASCVD), especially cardiac diseases including coronary artery disease (CAD) such as …
Evinacumab for pediatric patients with homozygous familial hypercholesterolemia
A Wiegman, S Greber-Platzer, S Ali, MD Reijman… - Circulation, 2024 - Am Heart Assoc
BACKGROUND: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic
disorder characterized by severely elevated low-density lipoprotein cholesterol (LDL-C) …
disorder characterized by severely elevated low-density lipoprotein cholesterol (LDL-C) …
Rosuvastatin exerts anti-atherosclerotic effects by improving macrophage-related foam cell formation and polarization conversion via mediating autophagic activities
X Zhang, Y Qin, X Wan, H Liu, C Lv, W Ruan… - Journal of Translational …, 2021 - Springer
Background Atherosclerosis is a chronic vascular disease posing a great threat to public
health. We investigated whether rosuvastatin (RVS) enhanced autophagic activities to inhibit …
health. We investigated whether rosuvastatin (RVS) enhanced autophagic activities to inhibit …
New algorithms for treating homozygous familial hypercholesterolemia
TR Tromp, M Cuchel - Current opinion in lipidology, 2022 - journals.lww.com
Hypercholesterolemia is notoriously difficult to control in most patients with HoFH, but multi-
LLT, including newer drugs, allows reduction of LDL-C to levels unimaginable until a few …
LLT, including newer drugs, allows reduction of LDL-C to levels unimaginable until a few …
Recent advances on Familial Hypercholesterolemia in children and adolescents
F Mainieri, VM Tagi, F Chiarelli - Biomedicines, 2022 - mdpi.com
Familial hypercholesterolemia is a common autosomal hereditary disorder characterized by
elevated concentrations of low-density lipoprotein cholesterol and the development of …
elevated concentrations of low-density lipoprotein cholesterol and the development of …