Metabolic engineering is a new field with applications in the production of chemicals, fuels,
materials, pharmaceuticals, and medicine at the genetic level. The field's novelty is in the …

We present here a broad overview of the field of metabolic engineering, describing in the
first section the key fundamental principles that define and distinguish it, as well as the …

Metabolic engineering is the directed improvement of cellular properties through the
modification of specific biochemical reactions or the introduction of new ones, with the use of …

Metabolic engineering has developed as a very powerful approach to optimising industrial
fermentation processes through the introduction of directed genetic changes using …

Shifting from chemical to biotechnological processes is one of the cornerstones of 21st
century industry. The production of a great range of chemicals via biotechnological means is …

The excretion of the aromatic amino acid l-tyrosine was achieved by manipulating three
gene targets in the wild-type Escherichia coli K12: The feedback-inhibition-resistant (fbr) …

Engineering of hyaluronic acid (HA) biosynthetic pathway in recombinant Escherichia coli as
production host is reported in this work. A hyaluronic acid synthase (HAS) gene, sphasA …

Illustrating techniques in model development, signal processing, data reconciliation, process
monitoring, quality assurance, intelligent real-time process supervision, and fault detection …

Metabolic engineering has been defined as the purposeful modification of intermediary
metabolism using recombinant DNA techniques. With this definition metabolic engineering …

Genome-scale metabolic reconstructions have proven to be valuable resources in
enhancing our understanding of metabolic networks as they encapsulate all known …